1613227-00-1Relevant articles and documents
Study of the stability of the 5-aminolevulinic acid tyrosine ester in aqueous solution
Gay, Sandrine,Martoccia, Carla,Zellweger, Matthieu,Wang, Qian,Wagnieres, Georges
, p. 228 - 238 (2014/06/09)
Photodynamic therapy based on photoactivable porphyrins (PAPs) can treat various dermatological conditions. The side-effects as well as the non-selective or insufficient accumulation of PAPs in the targeted tissues limit performances. We studied the stability in solution at different temperatures (21 °C; 4 °C), different pH values (7.5; 2.0), and as a function of time of 5-aminolevulinic acid's Tyrosine-ester, a molecule presenting interesting properties to selectively produce PAPs in blood vessels after topical application. Solutions of this precursor can be kept up to 24 h at refrigerated temperatures and under acidic pH. At room temperature or physiological pH, they must be prepared minutes before their use. ARKAT-USA, Inc.