5451-09-2Relevant articles and documents
Convenient syntheses of δ-aminolevulinic acid
Nudelman, Ayelet,Nudelman, Abraham
, p. 568 - 570 (1999)
Two convenient procedures for the synthesis of δ-aminolevulinic acid (5-ALA) are described.
A convenient method for introducing oxo group into the β-position of cyclic amines and its application to synthesis of δ-aminolevulinic acid
Matsumura,Takeshima,Okita
, p. 304 - 306 (1994)
Oxo group could be introduced into the β-position of N-methoxycarbonylated cyclic amines by utilizing electrochemical oxidation and/or m-chloroperbenzoic acid oxidation, and this method was applied to the preparation of δ-aminolevulinic acid, an intermediate of chlorophyll biosynthesis.
Preparation method of 5-aminolevulinic acid hydrochloride
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Paragraph 0038; 0061; 0068-0069, (2021/11/03)
The invention discloses a preparation method of 5-aminolevulinic acid hydrochloride, which comprises the following steps: by taking 1, 3-dichloroacetone as an initial raw material, reacting with Meldrum's acid or a derivative thereof, then carrying out ester exchange, ammoniation reaction and hydrolysis decarboxylation, and finally decolorizing, concentrating and recrystallizing to obtain the 5-aminolevulinic acid hydrochloride. The method is high in yield, convenient to operate, stable in quality and suitable for industrial production.
Preparation method 5 - ALA intermediate 5 - bromoolevulinic acid ester
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Paragraph 0034; 0053; 0057, (2021/09/22)
The invention relates to a preparation method of 5 - ALA intermediate 5 - bromoacetyl ester, which is characterized by comprising the following steps: (S1) reaction of the urotropine and a bromine source to prepare the urotropine bromine complex. (S2) Lourotropine bromide complex and levulinic acid ester reaction. Gave 5 - bromoolevulinic acid ester. Compared with the prior art, a bromo reagent such as liquid bromine and 5 - is used directly, NBS-site bromination product yield is increased 5 - 10% or more. The defect that 3 -position bromination or multi-site bromination product is large and separation is difficult in the bromination reaction is overcome. The method is cheap and easily available in raw materials, simple and convenient to operate and suitable for large-scale preparation 5 - ALA intermediate 5 - bromolevulinic acid ester .