1613232-74-8

Upstream product

• 88430-50-6 [1R,2R,3aS, 8bS]-(2,3,3a,8b-tetrahydro-2-hydroxyl-1-[(3S,4S)-3-hydroxyl-4-methyl-1-(E)-octen-6-ynyl]-1H-cyclopenta[b]benzofuran-5)-butanoic acid 
• 40248-34-8 6-trifluoroacetamido-1-hexanol 
• 51224-10-3 1-iodo-6-(trifluoroacetamido)hexane 

Relevant academic research and scientific papers

PROCESS OF MAKING PROSTACYCLIN COMPOUNDS WITH LINKER THIOL AND PEGYLATED FORMS

A process provides for producing chiral prostacyclin derivatives of Formula (I) in high yield from meso anhydrides.

CARRIER-LINKED PROSTANOID PRODRUGS

The present invention relates to carrier-linked prostanoid prodrugs of formula (I) Z1 -(X0 - L0 - PG0)y (I), wherein Z1, X0, L0, PG0 and y have the meaning as indicated in the description and claims; pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising the same. It further relates to their use as medicaments, especially for treating, controlling, delaying or preventing pulmonary arterial hypertension.