51224-10-3Relevant academic research and scientific papers
PROCESS OF MAKING PROSTACYCLIN COMPOUNDS WITH LINKER THIOL AND PEGYLATED FORMS
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Paragraph 0201, (2014/09/30)
A process provides for producing chiral prostacyclin derivatives of Formula (I) in high yield from meso anhydrides.
Zwitterionic oligonucleotides: A study on binding properties of 2′-O-aminohexyl modifications
Noe, Christian R.,Winkler, Johannes,Urban, Ernst,Gilbert, Matthias,Haberhauer, Georg,Brunar, Helmut
, p. 1167 - 1185 (2007/10/03)
2′-O-Aminohexyl side chains provide excellent conditions for zwitterionic interstrand and intrastrand interactions of oligonucleotides. 2′-O-Aminoalkylated phosphoramidites of adenosine and undine were synthesized and incorporated in increasing number int
PREPARATION OF ANOMERIC PAIRS OF 1-THIOGLYCOSIDES: USE OF ANOMERIZATION CATALYZED BY BORON TRIFLUORIDE
Connolly, Daniel T.,Roseman, Saul,Lee, Yuan C.
, p. 227 - 240 (2007/10/02)
Anomeric pairs of some alkyl 1-thioaldopyranosides of D-galactose, D-glucose, D-mannose, 2-acetamido-2-deoxy-D-glucose, 2-acetamido-2-deoxy-D-galactose, and L-fucose were prepared.The per-O-acetylated, 1,2-trans anomers of 6-(trifluoroacetamido)hexyl 1-thioaldopyranosides and 5-(methoxycarbonyl)pentyl 1-thioaldopyranosides were anomerized with boron trifluoride in dichloromethane.The anomeric mixtures were then separated by chromatography, using columns of either silica gel or an ion-exchange resin.De-blocking of the separated compounds provided pure anomers of 6-aminohexyl 1-thioaldopyranosides or 5-carboxypentyl 1-thioaldopyranosides.The aglycons of the latter glycosides were further extended by reaction with aminoacetaldehyde diethyl acetal, which, after deacetalization of the products, provided an ω-aldehydo group.These series of glycosides could be readily coupled to proteins or solid matrices.
