1613293-53-0

Basic information

• Product Name: C₂₄H₂₁ClFN₅O₅
• CAS NO: 1613293-53-0
• Molecular Weight: 513.913
• Mol File: 1613293-53-0.mol

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₁ClFN₅O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₁ClFN₅O₅(1613293-53-0)
• EPA Substance Registry System: C₂₄H₂₁ClFN₅O₅(1613293-53-0)

Safety Data

• Hazardous Substances Data: 1613293-53-0(Hazardous Substances Data)

Upstream product

• 314771-76-1 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline 
• 50607-30-2 piperidine-2,4-dione 
• 314771-88-5 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline 
• 162012-67-1 N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 
• 162012-70-6 4-chloro-7-fluoro-6-nitroquinazoline 
• 162012-69-3 7-fluoro-6-nitro-4-hydroxyquinazoline 
• 16499-57-3 7-fluoro-3,4-dihydroquinazolin-4-one 
• 446-32-2 4-fluoroanthranilic acid 

Relevant articles and documents

TARGETED COVALENT PROBES AND INHIBITORS OF PROTEINS CONTAINING REDOX-SENSITIVE CYSTEINES

Covalent, irreversible small-molecule inhibitors that modify the sulfenyl form (i.e., sulfenic acid, RSOH and sulfenamide, RSNR'2) of therapeutically important proteins (particularly kinases and phosphatases) are disclosed, where the compositions include a compound having a substituted aryl or heterocyclic core structure that promotes binding interactions with a specific protein, and a nucleophilic reaction center (carbon, nitrogen, sulfur, or phosphorous) that is capable of forming a covalent bond with a sulfenic acid- or sulfenamide-modified cysteine residue in the protein. Methods for synthesizing these compounds are also disclosed, as well as methods of using them for determining the bioactivity of a chemical composition comprising an active compound toward a specific protein and for determining the potency of an inhibitor against a specific protein.