1613309-66-2

Basic information

• Product Name: (4R,5S)-diphenylmethyl 5-(3,4-dichlorophenyl)-1-(diphenylphosphoryl)-5-methyl-4,5-dihydro-1H-imidazole-4-carboxylate
• Synonyms: (4R,5S)-diphenylmethyl 5-(3,4-dichlorophenyl)-1-(diphenylphosphoryl)-5-methyl-4,5-dihydro-1H-imidazole-4-carboxylate
• CAS NO: 1613309-66-2
• Molecular Weight: 639.518
• Mol File: 1613309-66-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R,5S)-diphenylmethyl 5-(3,4-dichlorophenyl)-1-(diphenylphosphoryl)-5-methyl-4,5-dihydro-1H-imidazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-diphenylmethyl 5-(3,4-dichlorophenyl)-1-(diphenylphosphoryl)-5-methyl-4,5-dihydro-1H-imidazole-4-carboxylate(1613309-66-2)
• EPA Substance Registry System: (4R,5S)-diphenylmethyl 5-(3,4-dichlorophenyl)-1-(diphenylphosphoryl)-5-methyl-4,5-dihydro-1H-imidazole-4-carboxylate(1613309-66-2)

Safety Data

• Hazardous Substances Data: 1613309-66-2(Hazardous Substances Data)

Upstream product

• 123176-34-1 diphenylmethyl 2-isocyanoacetate 
• 1613310-13-6 diphenylmethyl 2-formamidoacetate 
• 91-01-0 1,1-Diphenylmethanol 
• 2642-63-9 3',4'-dichloroacetophenone 
• 139752-39-9 1-(3,4-dichlorophenyl)ethanone oxime 

Downstream Products

• 1613310-04-5 (4R,5S)-diphenylmethyl 5-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1H-imidazole-4-carboxylate 

Relevant articles and documents

Direct catalytic enantio- and diastereoselective Mannich reaction of isocyanoacetates and ketimines

A catalytic asymmetric synthesis of imidazolines with a fully substituted β-carbon atom by a Mannich-type addition/cyclization reaction of isocyanoacetate pronucleophiles and N-diphenylphosphinoyl ketimines has been developed. When a combination of a cinchona-derived aminophosphine precatalyst and silver oxide was employed as a binary catalyst system, good reactivity, high diastereoselectivities (up to 99:1 d.r.), and excellent enantioselectivities (up to 99 % ee) were obtained for a range of substrates. Binary catalyst system: A catalytic asymmetric synthesis of imidazolines with a fully substituted β-carbon atom through a Mannich-type addition/cyclization reaction of isocyanoacetate pronucleophiles and N-diphenylphosphinoyl ketimines has been developed. By employing a cinchona-derived aminophosphine precatalyst and silver oxide as a binary catalyst system, good reactivity and high diastereo- and enantioselectivities were obtained.