1613310-08-9

Upstream product

• 1613310-00-1 (4R,5S)-diphenylmethyl 5-(2-fluorophenyl)-5-methyl-4,5-dihydro-1H-imidazole-4-carboxylate 
• 67-56-1 methanol 
• 1613310-07-8 C₁₀H₁₃FN₂O₂ 
• 364-81-8 2'-fluoroacetophenone oxime 
• 445-27-2 2'-Fluoroacetophenone 
• 921936-93-8 P,P-diphenyl-N-[1-(2-fluorophenyl)ethylidene]phosphinic amide 
• 1613309-62-8 (4R,5S)-diphenylmethyl 1-(diphenylphosphoryl)-5-(2-fluorophenyl)-5-methyl-4,5-dihydro-1H-imidazole-4-carboxylate 

Relevant academic research and scientific papers

Direct catalytic enantio- and diastereoselective Mannich reaction of isocyanoacetates and ketimines

A catalytic asymmetric synthesis of imidazolines with a fully substituted β-carbon atom by a Mannich-type addition/cyclization reaction of isocyanoacetate pronucleophiles and N-diphenylphosphinoyl ketimines has been developed. When a combination of a cinchona-derived aminophosphine precatalyst and silver oxide was employed as a binary catalyst system, good reactivity, high diastereoselectivities (up to 99:1 d.r.), and excellent enantioselectivities (up to 99 % ee) were obtained for a range of substrates. Binary catalyst system: A catalytic asymmetric synthesis of imidazolines with a fully substituted β-carbon atom through a Mannich-type addition/cyclization reaction of isocyanoacetate pronucleophiles and N-diphenylphosphinoyl ketimines has been developed. By employing a cinchona-derived aminophosphine precatalyst and silver oxide as a binary catalyst system, good reactivity and high diastereo- and enantioselectivities were obtained.