1613315-69-7

Basic information

• Product Name: C₂₇H₂₆N₄O₄S₂
• CAS NO: 1613315-69-7
• Molecular Weight: 534.66
• Mol File: 1613315-69-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₂₆N₄O₄S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₂₆N₄O₄S₂(1613315-69-7)
• EPA Substance Registry System: C₂₇H₂₆N₄O₄S₂(1613315-69-7)

Safety Data

• Hazardous Substances Data: 1613315-69-7(Hazardous Substances Data)

Upstream product

• 13922-41-3 1-Naphthylboronic acid 
• 100959-22-6 methyl 2-bromo-4-nitrobenzoate 
• 1613316-20-3 C₄₉H₄₆N₄O₄S₂ 
• 1613316-14-5 C₂₅H₂₈N₂O₃S 
• 1613316-08-7 C₂₅H₂₆N₂O₅S 
• 180977-37-1 4-nitro-2-(1-naphthyl)benzoic acid 
• 180977-38-2 4-nitro-2-(1-naphthyl)benzoic acid methyl ester 
• 1613316-26-9 C₃₀H₃₂N₄O₄S₂ 

Relevant articles and documents

Farnesyltransferase inhibitors: CAAX mimetics based on different biaryl scaffolds

Mimetics of the C-terminal CAAX tetrapeptide of Ras protein were designed as farnesyltransferase (FTase) inhibitors (FTIs) by replacing AA with o-aryl or o-heteroaryl substituted p-hydroxy- or p-aminobenzoic acid, while maintaining the replacement of C with 1,4-benzodioxan-2-ylmethyl or 2-amino-4- thiazolylacetyl residue as in previous CAAX mimetics. Both FTase inhibition and antiproliferative effect were showed by two thiazole derivatives, namely those with 1-naphthyl (10 and 10a) or 3-furanyl (15 and 15a) in the central spacer, and by the benzodioxane derivative with 2-thienyl (6 and 6a) in the same position. Accumulation of unprenylated RAS was demonstrated in cells incubated with 15a. Consistently with FTIs literature, such results delineate the biaryl scaffold not only as a spacer but also as a sensible area of these mimetic molecules, where modifications at the branching aromatic ring are not indifferent and should be matter of further investigation.