16135-53-8

Upstream product

• 22990-16-5 (+/-)-1,4-dihydro-6,7-dimethoxy-1-phenylisoquinolin-3(2H)-one 
• 77-78-1 dimethyl sulfate 
• 116616-78-5 6,7-dihydroxy-1-phenyl-2-methyl-1,4-dihydro-3(2H)-isoquinolinone 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 89652-37-9 4-hydroxy-3-methoxyphenyl acetic acid chloride 
• 622-29-7 N-Benzylidenemethylamine 
• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 
• 306-08-1 Homovanillic acid 
• 186581-53-3 diazomethane 
• 81438-45-1 7-Hydroxy-6-methoxy-2-methyl-1-phenyl-1,4-dihydro-2H-isoquinolin-3-one 

Downstream Products

• 116616-78-5 6,7-dihydroxy-1-phenyl-2-methyl-1,4-dihydro-3(2H)-isoquinolinone 
• 89192-62-1 (E)-4-(hydroxyimino)-2-methyl-6,7-dimethoxy-1-phenyl-1,4-dihydro-3(2H)-isoquinolinone 
• 89192-67-6 (E)-2-methyl-6,7-dimethoxy-1-phenyl-4--1,4-dihydro-3(2H)-isoquinolinone 

Relevant academic research and scientific papers

Propylphosphonic anhydride (T3P) mediated synthesis of β-lactams from imines and aryl-substituted acetic acids

β-Lactams were prepared from imines and aryl-substituted acetic acids using T3P as an activating agent. In most cases, good to excellent yields were obtained (up to 93%) and the trans-β-lactam was the exclusive or major diastereoisomer (confirmed through

SYNTHESIS OF NEW 1-ARYL-1,4-DIHYDRO-3(2H)-ISOQUINOLINONES WITH POTENTIAL EFFECT ON THE CENTRAL NERVOUS SYSTEM 2-METHYL- AND 6,7-DISUBSTITUTED DERIVATES

Syntheses were attempted of analogues of 1--1,4-dihydro-3(2H)-isoquinolinone, a compound of anticonvulsive action and prepared in this laboratory earlier, carrying now substituents at the ring-nitrogen and in the 6,7-posi

LITHIATION OF 1-ARYL-1,4-DIHYDRO-3(2H)-ISOQUINOLINONES AND THEIR N-METHYL DERIVATIVES

N-methyl analogues of several 1,4-dihydro-3(2H)-isoquinolinone derivatives have been prepared via methylation with dimethyl sulphate; in some experiments the O-methyl lactim ethers have also been isolated.The incorporation of lithium into the N-methyl com