1613627-58-9Relevant academic research and scientific papers
Regiodivergent kinetic resolution of terminal and internal rac -aziridines with malonates under dinuclear schiff base catalysis
Xu, Yingjie,Kaneko, Keiichi,Kanai, Motomu,Shibasaki, Masakatsu,Matsunaga, Shigeki
, p. 9190 - 9194 (2014)
Regiodivergent parallel kinetic resolution of aziridines with malonates was achieved under dinuclear Schiff base catalysis. The regiodivergent reaction proceeded under catalyst-control irrespective of the substituents on the aziridines, and 2.5-10 mol % of a Y(OTf)3/La(OiPr)3/a dinucleating Schiff base = 1:1:1 mixture gave versatile γ-amino acid derivatives in 96 → >99.5% ee. Not only terminal but also internal racemic aziridines reacted smoothly under suitably combined Lewis acid/Br?nsted base catalysis.
