1613637-87-8Relevant academic research and scientific papers
An I2-mediated aerobic oxidative annulation of amidines with tertiary amines: Via C-H amination/C-N cleavage for the synthesis of 2,4-disubstituted 1,3,5-triazines
Yan, Yizhe,Li, Zheng,Cui, Chang,Li, Hongyi,Shi, Miaomiao,Liu, Yanqi
, p. 2629 - 2633 (2018)
An iodine-mediated formal oxidative cycloaddition of amidines with tertiary amines was first demonstrated in air. Both symmetrical and unsymmetrical 2,4-disubstituted 1,3,5-triazines were obtained in up to 85% yields. It is noted that a tertiary amine was employed as a one carbon synthon of 1,3,5-triazines and two C-N bonds were formed in one pot. Control experiments revealed that the reaction underwent a radical pathway promoted by I+. The method is transition-metal-free, peroxide-free, and operationally simple to implement with a wide scope of substrates.
Transition metal-free assembly of 1,3,5-triazines using ethyl bromodifluoroacetate as C1 source
Yu, Xiaoxia,Zhou, Yao,Ma, Xingxing,Song, Qiuling
supporting information, p. 8079 - 8082 (2019/07/15)
An efficient transition metal-free annulation of amidine with ethyl bromodifluoroacetate to access 2,4-disubstituted-1,3,5-triazines is firstly presented. The desired symmetric and unsymmetric 2,4-disubstituted-1,3,5-triazines were obtained in decent yields via multiple C-N bond formation, in which ethyl bromodifluoroacetate is harnessed as a unique C1 synthon via quadruple cleavage. This reaction is transition metal-free, oxidant-free and simple in operation, and only lowly toxic inorganic wastes are generated.
A multi-substituted 1, 3, 5 - triazine (by machine translation)
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Paragraph 0100-0102, (2019/06/07)
The present invention discloses a multi-substituted 1, 3, 5 - triazine, in particular to in order to replace the carboxamidine hydrochloride as a reaction substrate, two fluorine chlorine sodium acetate as a carbon synthons, in the equivalent function of
Dichloromethane as C1 Building Block: Synthesis of 2,4-Disubstitued 1,3,5-Triazines via Copper-Catalyzed Aerobic C?H/C?Cl Cleavage
Yan, Yizhe,Cui, Chang,Wang, Jianyong,Li, Shaoqing,Liu, Yanqi
supporting information, p. 1166 - 1170 (2019/01/30)
A copper-catalyzed aerobic oxidative annulation of amidines with dichloromethane was first demonstrated. Using this novel approach, 16 examples of symmetrical 2,4-disubstitued 1,3,5-triazines and 7 examples of unsymmetrical ones were obtained with up to 82% yields. Moreover, a D-labeling experiment proved that dichloromethane was employed as the C1 building block and solvent. A primary kinetic isotope effect revealed that the C?H cleavage of dichloromethane might be a rate-determining step. This protocol provides a novel strategy for the synthesis of heterocycles. (Figure presented.).
A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF
Xu, Xiaowen,Zhang, Min,Jiang, Huanfeng,Zheng, Jia,Li, Yiqun
supporting information, p. 3540 - 3543 (2014/07/21)
A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare with the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents, making it a highly practical approach to access various 2,4-disubstituted-1,3,5-triazines.
