161372-07-2

Basic information

• Product Name: (S)-methyl 2-carbomethoxy-3-methyl-5,5-diphenylpent-4-enoate
• Synonyms: (S)-methyl 2-carbomethoxy-3-methyl-5,5-diphenylpent-4-enoate
• CAS NO: 161372-07-2
• Molecular Weight: 338.403
• Mol File: 161372-07-2.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: (S)-methyl 2-carbomethoxy-3-methyl-5,5-diphenylpent-4-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-methyl 2-carbomethoxy-3-methyl-5,5-diphenylpent-4-enoate(161372-07-2)
• EPA Substance Registry System: (S)-methyl 2-carbomethoxy-3-methyl-5,5-diphenylpent-4-enoate(161372-07-2)

Safety Data

• Hazardous Substances Data: 161372-07-2(Hazardous Substances Data)

Upstream product

• 39128-78-4 rac-1,1,-diphenyl-1-buten-3-yl acetate 
• 18424-76-5 dimethyl malonate sodium salt 
• 108-59-8 malonic acid dimethyl ester 
• 21711-87-5 rac-1,3,3-triphenylprop-2-enyl acetate 

Downstream Products

• 180964-67-4 ((S)-2-Methyl-4,4-diphenyl-but-3-enyl)-carbamic acid tert-butyl ester 
• 180964-63-0 3-Methyl-5,5-diphenylpent-4-enoic acid 
• 180964-61-8 Methyl 3-methyl-5,5-diphenylpent-4-enoate 

Relevant articles and documents

Palladium Catalysed Allylic Substitution Reactions of Prochiral and Racemic Allyl Acetates

The palladium catalysed reaction between non-symmetrical allyl acetates and sodiodimethylmalonate proceeds in high yields and enantioselectivities (up to 99percent ee) using a diphenylphosphinoaryl oxazoline ligand.

A new modular phosphite-pyridine ligand library for asymmetric Pd-catalyzed allylic substitution reactions: A study of the key Pd-π-allyl intermediates

A library of phosphite-pyridine ligands L1-L12 a-g has been successfully applied for the first time in the Pd-catalyzed allylic substitution reactions of several di- and trisubstituted substrates by using a wide range of C, N and O nucleophiles, among which are the little studied α-substituted malonates, β-diketones, and alkyl alcohols. The highly modular nature of this ligand library enables the substituents/configuration at the ligand backbone, and the substituents/configurations at the biaryl phosphite moiety to be easily and systematically varied. We found that the introduction of an enantiopure biaryl phosphite moiety played an essential role in increasing the versatility of the Pd-catalytic systems. Enantioselectivities were therefore high for several hindered and unhindered di- and trisubstituted substrates by using a wide range of C, N and O nucleophiles. Of particular note were the high enantioselectivities (up to>99 % ee) and high activities obtained for the trisubstituted substrates S6 and S7, which compare favorably with the best that have been reported in the literature. We have also extended the use of these new catalytic systems in alternative environmentally friendly solvents such as propylene carbonate and ionic liquids. Studies on the Pd-π-allyl intermediates provide a deeper understanding of the effect of ligand parameters on the origin of enantioselectivity. A library of phosphite-pyridine ligands has been successfully applied in the Pd-catalyzed allylic substitution reactions of several di- and trisubstituted substrates by using a wide range of C, N, and O nucleophiles. By carefully selecting the ligand components, high regio- and enantioselectivities (up to >99 % ee) and good activities have been achieved (see scheme). The NMR studies on the Pd-π-allyl intermediates provide a deeper understanding of the effect of ligand parameters on the origin of enantioselectivity. Copyright

Highly modular P-OP ligands in asymmetric allylic substitution

A library of highly modular P-OP ligands have been evaluated in Pd-catalysed allylic substitutions with C- and N-nucleophiles. Catalyst optimisation via a variation of the phosphino and phosphite substituents led to a 'lead' catalyst, which efficiently me