161372-82-3

Upstream product

• 5407-87-4 2-Amino-4,6-dimethylpyridine 
• 1711-07-5 3-fluorobenzoyl chloride 
• 455-38-9 3-fluorobenzoic acid 

Downstream Products

• 191938-41-7 N'-[1-(4,6-Dimethyl-pyridin-2-ylamino)-1-(3-fluoro-phenyl)-meth-(Z)-ylidene]-hydrazinecarboxylic acid ethyl ester 
• 191938-32-6 C₁₄H₁₅FN₄ 
• 173863-43-9 N-(4,6-Dimethyl-pyridin-2-yl)-3-fluoro-thiobenzamide 

Relevant academic research and scientific papers

N-pyridinyl(alkyl)polyhalogenobenzamides acting as TNF-α production inhibitors

A series of N-pyridinyl(methyl)fluorobenzamides issued from 2,4-dimethyl-6-aminopyridine and 3-aminomethylpyridine were synthesized and evaluated as inhibitors of TNF-α production. Although less active than the corresponding phthalimides, several pentaflu

Non-acidic antiinfiammatory compounds II. Synthesis and activity of 6-amino-2,4-lutidine derivatives

Benzamides I, phenylalkanamides II and cinnamamides III are structurally related to the antiinflammatory N-(4,6-dimethylpyridin-2-yl)benzamide I. These were synthesized and the transformation of the 2-aminopyridine nucleus of benzamides I into a 2-imino-1,2-dihydropyridine structure (compounds IV) was also carried out. Of the 49 new derivatives, the 3-fluorobenzamide 9 was the most patent in the oral treatment of carrageenen-induced peripheral edema; IC50 = 12.2 mg·kg-1. It was 3 times as active as benzamide 1, but the latter nevertheless had a better therapeutic index (LD5(/)IC50) of 52 against 23. Benzamide 1, a non-acidic antiinflammatory compound devoid of any blocking activity on cyclooxygenase, markedly reduces the production of reactive oxygen species in rat peritoneal macrophages. This compound probably acts at the membrane, perhaps by interference with transmembrane events.