191938-41-7Relevant academic research and scientific papers
Synthesis and anti-inflammatory activity of polyazaheterocyclic derivatives of 6-amino-2,4-lutidine and their precursors
Robert, Jean-Michel,Rideau, Odile,Robert-Piessard, Sylvie,Duflos, Muriel,Le Baut, Guillaume,Grimaud, Nicole,Juge, Marcel,Petit, Jean-Yves
, p. 635 - 642 (2007/10/03)
Derivatives of N-(4,6-pyridin-2-yl)arylcarboxamides resulting from the integration of the amidic function into 4H-1,2,4-triazole, triazol-3(2H)-one and 1H-tetrazole rings were evaluated as potential anti-inflammatory compounds. The eve of activity decreased as compared to carboxamides nevertheless their precursors and notably the corresponding amidrazones exhibited potent activity; amidrazone 21, whose ID50 was 34.4 mg · kg-1 in the rat paw edema test, was selected for further investigation. These heteroarylcarboxamide derivatives could represent an interesting alternative to classical non-steroidal anti-inflammatories in so far as they partly act by inhibition of tumor necrosis factor-α production.
