1613733-72-4

Upstream product

• 859199-06-7 1-(5-bromo-4-methylthiophen-2-yl)ethan-1-one 
• 158401-00-4 1-(3,4,5-trichloro-phenyl)-2,2,2-trifluoro-ethanone 

Downstream Products

• 1613733-73-5 C₁₅H₈BrCl₃F₃NOS 
• 1613733-74-6 C₁₆H₉Cl₃F₃NO₃S 

Relevant academic research and scientific papers

PROCESS FOR THE ENANTIOMERIC ENRICHMENT OF DIARYLOXAZOLINE DERIVATIVES

The present invention concerns a process for the manufacture of the S-enantiomer of a compound of formula (I) wherein the variables are as defined in the specification and claims, comprising the steps of (A) separating a racemic compound of formula (II) wherein R', R and R' and Y are as defined above and Z is Q; or is halogen, amino, carboxy (-COOH); into the enantiomers and collecting the S-enantiomer; (B) if Z is other than Q, converting the S-enantiomer of formula (II) from step (A) to a S- enantiomer of formula (I); (C) racemizing the R-enantiomer of formula (II) from step (A) in a reaction medium comprising a base and an aprotic organic solvent at a temperature of from 30°C to 150°C, and (D) subjecting the racemate from step (C) to a further manufacturing cycle comprising step (A) and optionally (B). Accordingly, a cyclic process is provided, wherein the undesired enantiomer of a first enantiomer separation step is racemized and then phased in a further enantiomer separation step.