1613810-39-1Relevant articles and documents
Synthesis, spectrophotometric, voltammetric, and density functional theory studies of tetrahydro[3,2-b]indolocarbazoles for sensing small molecules
Al-Ahmed, Zehbah Ali,Habib, Ibrahim H. I.,Khattab, Reham R.,Abdelhameed, Reda M.,El-Naggar, Mohamed,Abu Bieh, Moursi H.,Pisarevd, Sergey A.,Voronkov, Andrey,El Sayed, Mardia T.
, p. 127 - 136 (2021)
Absorption spectra of tetrahydro[3,2-b]indolocarbazoles (THICZs) with respective molecular property and alkyl substituents have been prerecorded in diverse solvents in the scope between 200 and 600 nm for very fewer times in the literary study. The photo-
Tetrahydroindolocarbazoles (THICZs) as new class of urokinase (uPA) inhibitors: Synthesis, anticancer evaluation, DNA-damage determination, and molecular modelling study
El-Sharief, Marwa A.M.Sh.,El-Naggar, Mohamed H.,Ahmed, Entesar M.,El-Messery, Shahenda M.,Mahmoud, Abeer E.,Ali, Mamdouh M.,Salem, Lamiaa M.,Mahrous, Karima F.,El Sayed, Mardia T.
, p. 545 - 554 (2018/07/25)
Tetrahydroindolocarbazoles (THICZs) with versatile substituents, have been designed, synthesized, structure characterized, then investigated for their in-vitro anticancer screening, urokinase inhibition (uPA) evaluated, DNA-damage determination was further explored. Compounds 5, 8, 10 and 17 displayed the most promising antitumor activities against the breast cancer cell line as compared to the standard drug, doxorubicin with IC50 = 5.24 ± 0.37, 4.00 ± 0.52, 7.20 ± 0.90 and 9.60 ± 1.10 μg/ml (versus 3.30 ± 0.48 μg/ml for doxorubicin). Compounds 5, 8, 10 and 17 represents the most significant uPA inhibitors of our study with IC50 of 3.80, 2.70. 4.75, 10.80 (ng/ml) respectively. The expression levels of CDKN2A gene were decreased in 8, 10 and 17 cell lines as compared to those in positive control samples. Cell lines treated with 5, 8, 10 and 17 clearly observed a high score of damaged DNA cells. A deeper examination revealed that our hetroaromatics showed an extensive hydrogen bonding interactions that is required in the S pocket which is important for activity Arg 217, Gly 219, Gly 216, Lys 143 and Ser 190. So we present THICZs as promising uPA inhibitors expected as significant promise for further development as anti-invasiveness drugs.
Synthesis, photophysical and electrochemical properties of novel 6,12-di(thiophen-2-yl) substituted indolo[3,2-b]carbazoles
Irgashev, Roman A.,Teslenko, Anton Yu.,Zhilina, Ekaterina F.,Schepochkin, Aleksandr V.,El'Tsov, Oleg S.,Rusinov, Gennady L.,Charushin, Valery N.
, p. 4685 - 4696 (2014/06/23)
Novel 5,11-dialkyl-6,12-di(thiophen-2-yl) substituted 5,11-dihydroindolo[3, 2-b]carbazoles have been obtained and plausible ways for their further modifications via the Friedel-Crafts reaction are presented. The formylation of these indolo[3,2-b]carbazoles with dichloromethyl alkyl esters catalysed by Lewis acids leads to the formation of the corresponding 2,8-diformyl derivatives. Applicability of this formylation method for modification of indolo[3,2-b]carbazoles bearing electron-rich aromatic substituents at C-6 and C-12 has also been demonstrated. The Knoevenagel condensation of 2,8-dialdehydes with active methylene nitriles has been studied. The measurements of optical and redox properties for a number of new indolo[3,2-b]carbazoles have been performed.
