1614-12-6 Usage
Description
1-Aminobenztriazole (1614-12-6) is a pan-specific cytochrome P450 inhibitor acting as a suicide substrate.1,2?Blocks omega-oxidation of arachidonic acid but not its epoxidation.3
Chemical Properties
yellow to beige or light brown crystalline powder
Uses
Different sources of media describe the Uses of 1614-12-6 differently. You can refer to the following data:
1. 1-Aminobenzotriazole is used as a Suicide inhibitor of cytochrome P450 and chloroperoxidase, an inhibitor of oxidative drug metabolism in biochemical pharmacology and toxicology studies.
2. 1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H2O2-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.
Biochem/physiol Actions
1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.
References
1) Mugford?et al.?(1995),?1-Aminobenzotriazole-Induced Destruction of Hepatic and Renal Cytochrome P450 in Male Sprague-Dawley Rats; Fundam. Appl. Tox.,?19?43
2) Emoto?et al.?(2005),?In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations in Human Liver Microsomes: A Comparison With SKF-525A; Drug Metab. Pharmacokinet.,?20?351
3) Su?et al.?(1998),?Inhibition of Renal Arachidonic Acid Omega-Hydroxylase Activity With ABT Reduces Blood Pressure in the SHR; Am. J. Physiol.,?275?R426
Check Digit Verification of cas no
The CAS Registry Mumber 1614-12-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,1 and 4 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1614-12:
(6*1)+(5*6)+(4*1)+(3*4)+(2*1)+(1*2)=56
56 % 10 = 6
So 1614-12-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2
1614-12-6Relevant articles and documents
A new 1,2,3-triazolo[1,2]benzodiazepine ring system
Knight, David W.,Little, Paul B.
, p. 5037 - 5040 (1997)
Dianion 2 derived from N-Boc-aminobenzotriazole 1 condenses in a [1.2]fashion with α,β-unsaturated aldehydes; subsequent oxidation of the resulting allylic alcohols 7 using manganese(IV) oxide or, less effectively, treatment of the derived acetates 10 with Pd(0), results in direct formation of the novel triazolo[1,2]-benzodiazepines 9 and 11 by intramolecular addition of the pendant amino group.
NEW SUBSTITUTED BIPHENYL ANALOGUES AS DUAL INHIBITORS OF AROMATASE AND SULFATASE
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Page/Page column 37, (2015/07/16)
Provided are new biphenyl derivatives of formula (Ia). These compounds act as aromatase and sulfatase inhibitors. They are particularly useful for treating pathological conditions or diseases in which aromatase and sulfatase are involved. Moreover, provided are processes for the preparation of these compounds and pharmaceutical compositions containing said products and their use for the preparation of a medicament, in particular for the treatment of diseases characterized by aromatase and sulfatase activity such as hormone-dependent cancers.
