A new 1,2,3-triazolo[1,2]benzodiazepine ring system

Article abstract of DOI:10.1016/S0040-4039(97)01064-2

Dianion 2 derived from N-Boc-aminobenzotriazole 1 condenses in a [1.2]fashion with α,β-unsaturated aldehydes; subsequent oxidation of the resulting allylic alcohols 7 using manganese(IV) oxide or, less effectively, treatment of the derived acetates 10 with Pd(0), results in direct formation of the novel triazolo[1,2]-benzodiazepines 9 and 11 by intramolecular addition of the pendant amino group.