161401-76-9

Upstream product

• 104274-42-2 (S)-3-Amino-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propionic acid ethyl ester 
• 17445-33-9 (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)propanoic acid 
• 161401-75-8 (S)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propionic acid ethyl ester 
• 36326-38-2 ethyl (E)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate 

Downstream Products

• 161401-77-0 2,6-Dichloro-benzoic acid (2R,3S)-3-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-ethoxycarbonyl-2-hydroxy-butyl ester 

Relevant academic research and scientific papers

Synthesis of P1 Aspartate-Based Peptide Acyloxymethyl and Fluoromethyl Ketones as Inhibitors of Interleukin-1β-Converting Enzyme

Improved procedures have been developed for the synthesis of P1 aspartate-based 2,6-dichlorobenzoyloxymethyl ketone 1 and fluoromethyl ketone 2, the prodrugs of two potent ICE-inhibitors. 1 was prepared from (R)-trans-4,5-O-isopropylidene-4,5-dihydroxy-2-