36326-38-2

Basic information

• Product Name: (E)-3-(2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-ACRYLIC ACID ETHYL ESTER
• Synonyms: (E)-3-(2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-ACRYLIC ACID ETHYL ESTER;(R,E)-ETHYL 3-(2,2-DIMETHYL-1,3-DIOXOLAN-4-YL)ACRYLATE;(1R,4R)-METHYL 4-(HYDROXYMETHYL)CYCLOHEXANECARBOXYLATE(WXC08504)
• CAS NO: 36326-38-2
• Molecular Formula: C₁₀H₁₆O₄
• Molecular Weight: 200.23164
• Mol File: 36326-38-2.mol
• Article Data: 32

Chemical Properties

• Boiling Point: 241.0±0.0 °C(Predicted)
• Appearance: /
• Density: 1.102±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (E)-3-(2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-ACRYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-ACRYLIC ACID ETHYL ESTER(36326-38-2)
• EPA Substance Registry System: (E)-3-(2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-ACRYLIC ACID ETHYL ESTER(36326-38-2)

Safety Data

• Hazardous Substances Data: 36326-38-2(Hazardous Substances Data)

Usage

General Description

(E)-3-(2,2-Dimethyl-[1,3]dioxolan-4-yl)-acrylic acid ethyl ester is a chemical compound with the molecular formula C10H16O4. It is an ethyl ester of acrylic acid that contains a dioxolane ring in its structure. (E)-3-(2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-ACRYLIC ACID ETHYL ESTER is used in the production of polymers, adhesives, and coatings in various industrial applications. It is also used as a reagent in organic synthesis and as a building block for the synthesis of other organic compounds. (E)-3-(2,2-Dimethyl-[1,3]dioxolan-4-yl)-acrylic acid ethyl ester is a colorless liquid with a characteristic odor, and it is important to handle it with care due to its potential health hazards.

Upstream product

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• 14347-78-5 1,2-O-isopropylidene-D-glycerol 
• 22323-80-4 (4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 1128-23-0 L-gulono-1,4-lactone 
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• 84379-53-3 2-O-benzyl-3,4-O-isopropylidene-L-threitol 
• 98733-24-5 calcium bis[(2R)-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl](hydroxy)acetate] 
• 15042-01-0 5,6-O-isopropylidene-L-ascorbic acid 
• 91274-05-4 (2S,3S)-1,2-O-isopropylidene-1,2,3,4-tetrol 
• 92973-40-5 methyl (2R,3S)-3,4-O-isopropylidene-2,3,4-trihydroxybutanoate 
• 64870-23-1 1,2:5,6-di-O-isopropylidene-D-mannitol 

Downstream Products

• 105865-97-2 Ethyl 4,5-O-isopropylidene-(3R/S,4S)-4,5-dihydroxy-3-phenylthiopentanoate 
• 105865-98-3 Ethyl 4,5-O-isopropylidene-(3S,4S)-4,5-dihydroxy-3-phenylthiopentanoate 
• 105865-97-2 Ethyl 4,5-O-isopropylidene-(3R,4S)-4,5-dihydroxy-3-phenylthiopentanoate 
• 112837-17-9 (R)-(+)-5-(hydroxymethyl)furan-2(5H)-one 
• 866594-60-7 (3aS,4S,6aR)-4-methoxy-tetrahydro-furo[3.4-b]furan-2(3H)-one 
• 156928-09-5 (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol 
• 1265592-08-2 (2S,3R)-tert-butyl 2-(benzyloxy)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-4-enoate 
• 1265592-11-7 (2R,3R)-1-tert-butoxy-3-((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-oxopent-4-en-2-yl-4-nitrobenzoate 
• 1265592-13-9 (2R,3R)-tert-butyl 2-(benzyloxy)-3-((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-4-enoate 
• 1403352-71-5 (4S,5S)-5-(hydroxymethyl)-4-(phenylthio)dihydrofuran-2(3H)-one 
• 1403352-70-4 (4R,5S)-5-(hydroxymethyl)-4-(phenylthio)dihydrofuran-2(3H)-one 
• 909395-03-5 tert-butyl (((2R,3S,5R)-5-methoxy-3-vinyl-tetrahydrofuran-2-yl)methoxy)diphenylsilane 
• 1403352-48-6 tert-butyl[(2R,3S,5R)-3-((Z)-2-iodovinyl)-5-methoxytetrahydrofuran-2-ylmethoxy]diphenylsilane 
• 1403352-78-2 (Z)-3-[(2R,3S,5R)-2-(tert-butyldiphenylsilanyloxymethyl)-5-methoxytetrahydrofuran-3-yl]acrylic acid methyl ester 

Relevant articles and documents

MONOBACTAM COMPOUNDS AND USE THEREFOR

Monobactam compounds and a use therefor. Specifically provided are chemical compounds represented by formula (I) or isomers, pharmaceutically acceptable salts, solvates, crystals, or prodrugs thereof, preparation methods therefor, pharmaceutical compositions containing said compounds, and a use of said compounds or compositions in treating bacterial infection. The present compounds feature excellent antibacterial activity, and have great hopes of becoming a therapeutic agent for bacterial infection.

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A flexible synthetic approach to biologically active sphingoid base-like compounds with a 3-amino-1,2-diol framework was achieved through a [3,3]-sigmatropic rearrangement and late stage olefin cross-metathesis as the key transformations. The stereochemistry of the newly created stereogenic centre was assigned via a single crystal X-ray analysis of the (4S,5R)-5-(hydroxymethyl)-4-vinyloxazolidine-2-thione. In order to rationalise the observed stereoselectivity of the aza-Claisen rearrangement, DFT calculations were carried out. The targeted isomeric sphingoid bases were screened in vitro for anticancer activity on a panel of seven human malignant cell lines. Cell viability experiments revealed that C17-homologues are more active than their C12 congeners.

PROCESS FOR THE PREPARATION OF [(1 S,2R)-3-[[(4-AMINOPHENYL)SULFONYL] (2-METHYLPROPYL)AMINO]-2-HYDROXY-1 -(PHENYLMETHYL)PROPYL]-CARBAMIC ACID (3R,3AS,6AR)HEXAHYDRO FURO[2,3-B]FURAN-3-YL ESTER AND ITS AMORPHOUS FORM

The present invention relates to an improved process for the preparation of [(1 S,2R)-3-[ [(4-aminophenyl)sulfonyl] (2-methylpropyl)amino]-2-hydroxy- 1 -(phenylmethyl)propyl] - carbamic acid (3R,3aS,6aR)hexahydrofuro[2,3-b]furan-3-yl ester compound of formula- 1 represented by the following structural formula: