1614219-62-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 23165-29-9 3,5-bistrifluoromethylphenylisothiocyanate 
• 1030603-66-7 tert-butyl (1R,2R)-2-isothio-cyanatocyclohexylcarbamate 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 
• 146504-07-6 tert-butyl ((1R,2R)-2-aminocyclohexyl)carbamate 

Downstream Products

• 860994-58-7 1-((1R,2R)-2-aminocyclohexyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea 

Relevant academic research and scientific papers

A Chiral Thiourea as a Template for Enantioselective Intramolecular [2 + 2] Photocycloaddition Reactions

A chiral (1R,2R)-diaminocyclohexane-derived bisthiourea was found to exhibit a significant asymmetric induction in the intramolecular [2 + 2] photocycloaddition of 2,3-dihydropyridone-5-carboxylates. Under optimized conditions, the reaction was performed with visible light employing 10 mol % of thioxanthone as triplet sensitizer. Due to the different electronic properties of its carbonyl oxygen atoms, a directed binding of the substrate to the template is possible, which in turn enables an efficient enantioface differentiation.

New simple primary amine-thiourea organocatalysts and their application in asymmetric conjugate addition

A kind of simple primary amine-thiourea organocatalysts was developed. And their application in asymmetric conjugate addition of ketone to nitroalkene was investigated. In the presence of the new primary amine-thiourea, the conjugate addition of ketone to