1614235-11-8Relevant articles and documents
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2, 3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents
Zhang, Xin,Raghavan, Sudhir,Ihnat, Michael,Thorpe, Jessica E.,Disch, Bryan C.,Bastian, Anja,Bailey-Downs, Lora C.,Dybdal-Hargreaves, Nicholas F.,Rohena, Cristina C.,Hamel, Ernest,Mooberry, Susan L.,Gangjee, Aleem
, p. 3753 - 3772 (2014/07/07)
The design, synthesis and biological evaluations of fourteen 4-substituted 2,6-dimethylfuro[2,3-d]pyrimidines are reported. Four compounds (11-13, 15) inhibit vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor