1614257-11-2

Basic information

• Product Name: 2-[1-(4-ethylphenyl)-1H-[1,2,3]triazol-4-ylmethylsulfanyl]benzoxazole
• Synonyms: 2-[1-(4-ethylphenyl)-1H-[1,2,3]triazol-4-ylmethylsulfanyl]benzoxazole
• CAS NO: 1614257-11-2
• Molecular Weight: 336.417
• Mol File: 1614257-11-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[1-(4-ethylphenyl)-1H-[1,2,3]triazol-4-ylmethylsulfanyl]benzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(4-ethylphenyl)-1H-[1,2,3]triazol-4-ylmethylsulfanyl]benzoxazole(1614257-11-2)
• EPA Substance Registry System: 2-[1-(4-ethylphenyl)-1H-[1,2,3]triazol-4-ylmethylsulfanyl]benzoxazole(1614257-11-2)

Safety Data

• Hazardous Substances Data: 1614257-11-2(Hazardous Substances Data)

Upstream product

• 52924-71-7 2-(prop-2-yn-1-ylsulfanyl)benzo[d]oxazole 
• 128654-33-1 1-azido-4-ethylbenzene 
• 2382-96-9 2-sulfanyl-1,3-benzoxazole 

Relevant articles and documents

Synthesis of novel 2-mercaptobenzoxazole based 1,2,3-triazoles as inhibitors of proinflammatory cytokines and suppressors of COX-2 gene expression

A library of novel bis-heterocycles containing 2-mercaptobenzoxazole based 1,2,3-triazoles has been synthesized using click chemistry approach. The compound 4 exhibited the most potent in vivo anti-inflammatory activity with 66.66% and 61.11% inhibition in comparison to celecoxib which showed 72.22% and 65.55% inhibition after 3 h and 5 h respectively. The compounds 4 and 9 suppressed the COX-2 gene expression by 0.94 and 0.79 fold and exhibited a selective index (COX-1/COX-2) of 64.79 and 66.47 respectively in comparison to celecoxib (SI value of 75.56). The in silico molecular docking studies showed the interactions of these molecules with Tyr-59, Tyr-119 and Gly-121. When compared with the standard drug celecoxib, compounds 4, 5, 7, 9 and 16 did not cause any gastric ulceration.