161452-12-6

Basic information

• Product Name: N-tert-Butyl-2,4,6-triMethylbenzenesulfonaMide, 97%
• Synonyms: N-tert-Butyl-2,4,6-triMethylbenzenesulfonaMide, 97%
• CAS NO: 161452-12-6
• Molecular Formula: C₁₃H₂₁NO₂S
• Molecular Weight: 255.37634
• Mol File: 161452-12-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-tert-Butyl-2,4,6-triMethylbenzenesulfonaMide, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-Butyl-2,4,6-triMethylbenzenesulfonaMide, 97%(161452-12-6)
• EPA Substance Registry System: N-tert-Butyl-2,4,6-triMethylbenzenesulfonaMide, 97%(161452-12-6)

Safety Data

• Hazardous Substances Data: 161452-12-6(Hazardous Substances Data)

Upstream product

• 773-64-8 2-mesitylenesulphonyl chloride 
• 384-98-5 2,4,6-trimethylbenzene-1-sulfonyl fluoride 
• 75-64-9 tert-butylamine 

Downstream Products

• 544423-60-1 N,N-t-butyl-(mesitylenesulfonyl)-4-aminobutyronitrile 
• 161452-22-8 N¹,N⁵,N¹⁰,N¹⁴-tetrakis(mesitylenesulfonyl)-N¹-(tert-butyl)-N¹⁴-ethylhomospermine 
• 4543-58-2 2,4,6-trimethylbenzenesulfonamide 
• 161452-18-2 N-(tert-butyl)-N-(4-bromobutyl)mesitylenesulfonamide 

Relevant articles and documents

A Broad-Spectrum Catalytic Amidation of Sulfonyl Fluorides and Fluorosulfates**

A broad-spectrum, catalytic method has been developed for the synthesis of sulfonamides and sulfamates. With the activation by the combination of a catalytic amount of 1-hydroxybenzotriazole (HOBt) and silicon additives, amidations of sulfonyl fluorides and fluorosulfates proceeded smoothly and excellent yields were generally obtained (87–99 %). Noticeably, this protocol is particularly efficient for sterically hindered substrates. Catalyst loading is generally low and only 0.02 mol % of catalyst is required for the multidecagram-scale synthesis of an amantadine derivative. In addition, the potential of this method in medicinal chemistry has been demonstrated by the synthesis of the marketed drug Fedratinib via a key intermediate sulfonyl fluoride 13. Since a large number of amines are commercially available, this route provides a facile entry to access Fedratinib analogues for biological screening.

Copper-Catalyzed, N-Directed Csp3-H Trifluoromethylthiolation (-SCF3) and Trifluoromethylselenation (-SeCF3)

A direct and versatile copper-catalyzed trifluoromethylthiolation and trifluoromethylselenation of primary, secondary, and tertiary aliphatic C-H bonds was developed. The reaction provides direct access to molecules containing these emerging moieties in the presence of a wide range of common functional groups and in complex molecular environments.

Antiproliferative Properties of Polyamine Analogues: A Structure-Activity Study

A basis set of polyamine analogues was designed and synthesized.These compounds were used to initiate a systematic investigation of the role of chain length, terminal nitrogen alkyl group size, and symmetry of the methylene backbone in the antineoplastic