161452-63-7

Basic information

• Product Name: (2R,3R)-1,4-anhydro-5-O-benzyl-3-C-benzyloxymethyl-2-C-(2,6-diaminopurin-9-yl)-2,3-dideoxy-D-arabitol
• Synonyms: (2R,3R)-1,4-anhydro-5-O-benzyl-3-C-benzyloxymethyl-2-C-(2,6-diaminopurin-9-yl)-2,3-dideoxy-D-arabitol
• CAS NO: 161452-63-7
• Molecular Weight: 460.536
• Mol File: 161452-63-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3R)-1,4-anhydro-5-O-benzyl-3-C-benzyloxymethyl-2-C-(2,6-diaminopurin-9-yl)-2,3-dideoxy-D-arabitol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-1,4-anhydro-5-O-benzyl-3-C-benzyloxymethyl-2-C-(2,6-diaminopurin-9-yl)-2,3-dideoxy-D-arabitol(161452-63-7)
• EPA Substance Registry System: (2R,3R)-1,4-anhydro-5-O-benzyl-3-C-benzyloxymethyl-2-C-(2,6-diaminopurin-9-yl)-2,3-dideoxy-D-arabitol(161452-63-7)

Safety Data

• Hazardous Substances Data: 161452-63-7(Hazardous Substances Data)

Upstream product

• 132617-86-8 1,3-dideoxy-3-<(phenylmethoxy)methyl>-5-O-(phenylmethyl)-D-ribofuranose 
• 69827-91-4 3-deoxy-1,2-O-(1-methylethylidene)-3-<(phenylmethoxy)methyl>-5-O-(phenylmethyl)-α-D-ribofuranose 
• 161452-61-5 (3S)-1,4-anhydro-5-O-benzyl-3-C-benzyloxymethyl-3-deoxy-2-O-methanesulfonyl-D-ribitol 
• 1904-98-9 2,6-diaminopurine 

Relevant articles and documents

Nucleosides and nucleotides. 132. Synthesis and biological evaluations of ring-expanded oxetanocin analogues: Purine and pyrimidine analogues of 1,4-anhydro-2-deoxy-D-arabitol and 1,4-anhydro-2-deoxy-3-hydroxymethyl-D-arabitol

(2R)-2-C-(Adenin-9-yl)- 1,4-anhydro-2-deoxy-D-arabitol (2) and (2R, 3R)-2-C-(adenin-9-yl)- 1,4-anhydro- 2,3-dideoxy-3-C-hydroxymethyl-D-arabitol (3), and their 2,6-diaminopurine analogues 4 and 5 were synthesized from corresponding 1,4-anhydro-D-ribitol derivatives, which were readily obtained from D-glucose. The corresponding guanine isonucleosides 6 and 7 were obtained from 4 and 5 by enzymatic deamination with adenosine deaminase. Pyrimidine counterparts 8 and 9 were synthesized via construction of the pyrimidine moiety from amino derivatives of the 1,4-anhydro-D-arabitol derivatives. Antiviral activity of these ring-expanded derivatives of oxetanocins towards HSV-1, HSV-2, HCMV, and HBV in vitro was examined along with their cytotoxicity against L1210 and KB cells in vitro.