69827-91-4Relevant articles and documents
Stereoselective cyclopropanation in the synthesis of 3'-deoxy-3'-C-hydroxymethyl-2',3'-methylene-uridine
Komsta, Zofia,Mayes, Benjamin A.,Moussa, Adel,Shelbourne, Montserrat,Stewart, Alistair,Tyrrell, Andrew J.,Wallis, Laura L.,Weymouth-Wilson, Alexander C.,Yurek-George, Alexander
supporting information, p. 4878 - 4880 (2015/04/27)
The synthesis of the novel 2',3'-cyclopropane nucleoside 3'-deoxy-3'-C-hydroxymethyl-2',3'-methylene-uridine is described. Stereoselective construction of the cyclopropane ring was achieved via Simmons-Smith cyclopropanation of a benzyl protected silyl enol ether, which was itself derived from 1,2-O-isopropylidene-α-D-xylofuranose.
Synthesis and antiviral activity of novel isonucleoside analogs
Tino,Clark,Field,Jacobs,Lis,Michalik,McGeever-Rubin,Slusarchyk,Spergel,Sundeen,Tuomari,Weaver,Young,Zahler
, p. 1221 - 1229 (2007/10/02)
A series of branched-chain sugar isonucleosides was synthesized and evaluated for antiviral activity against herpesviruses. The preparation of homochiral [3S-(3α,4β,5α)]-2-amino-1,9-dihydro-9-[tetrahydro-4,5- bis(hydroxymethyl)-3-furanyl]-6H-purin-6-one (
SYNTHESIS OF OXETANOCIN
Wilson, F. X.,Fleet, G. W. J.,Vogt, K.,Wang, Y.,Witty, D. R.,et al.
, p. 6931 - 6934 (2007/10/02)
A low yield synthesis of oxetanocin and its α-epimer by reaction of adenine with a protected 3-hydroxymethyl-2-chlorooxetane is described; attempts to synthesise other C-2'alkyl analogues of oxetanocin by analogous reactions indicate a limitation of this strategy for the synthesis of oxetane nucleosides.An intermediate for the synthesis of C-nucleoside analogues of oxetanocin is reported.