69827-91-4

Upstream product

• 69827-89-0 ((3aR,5S,6R,6aR)-5-Hydroxymethyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl)-methanol 
• 100-39-0 benzyl bromide 
• 34311-67-6 3-deoxy-3-(hydroxymethyl)-1,2-O-(1-methylethylidene)-5-O-(phenylmethyl)-α-D-ribofuranose 
• 100-44-7 benzyl chloride 
• 23202-83-7 5-benzyl-1,2-O-isopropylidene-α-D-xylofuranose 
• 34311-63-2 5-O-benzyl-3-oxo-1,2-O-isopropylidene-α-D-xylofuranose 
• 26293-59-4 3-deoxy-3-methylene-1,2-O-(1-methyethylidene)-5-O-(phenylmethyl)-α-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 6893-65-8 1,2-di-O-isopropylidene-5-O-tosyl-D-xylofuranose 
• 69832-48-0 ((3aR,5S,6R,6aR)-tetrahydro-2,2-dimethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)furo[2,3-d][1,3]dioxol-6-yl)methanol 
• 2847-00-9 1,2:5,6-di-O-isopropylidene-α-D-hexofuran-3-ulose 
• 26277-33-8 (R)-1-((3aR,5S,6R,6aR)-6-Hydroxymethyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethane-1,2-diol 
• 81722-81-8 1,2:5,6-Di-O-isopropyliden-3-C-<(trimethylsilyl)methyl>-α-D-allofuranose 
• 55174-91-9 (-)-1,2-O-isopropylidene-5-O-pivaloyl-α-D-xylofuranose 

Downstream Products

• 120567-25-1 (2S,3R)-1,4-Bis-benzyloxy-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-2-ol 
• 1026404-30-7 (3R,4S,5S)-4,5-Bis-benzyloxymethyl-tetrahydro-furan-2,3-diol 
• 132617-86-8 1,3-dideoxy-3-<(phenylmethoxy)methyl>-5-O-(phenylmethyl)-D-ribofuranose 
• 871578-68-6 5-O-benzyl-3-C-benzyloxymethyl-3-deoxy-1-O-methyl-D-ribofuranoside 
• 871578-72-2 (2'R,3'S,4'R)-1-(2',3'-di-benzyloxymethyl-tetrahydrofuran-4'-yl)-3-methoxycarbonyl-1,2,4-triazole 
• 871578-74-4 (2'R,3'S,4'R)-1-(2',3'-di-benzyloxymethyl-tetrahydrofuran-4'-yl)-3-aminocarbonyl-1,2,4-triazole 
• 132523-63-8 1,3-dideoxy-3-<(phenylmethoxy)methyl>-5-O-(phenylmethyl)-D-ribofuranose 2-(4-methylbenzenesulfonate) 
• 132523-62-7 3-deoxy-3-<(phenylmethoxy)methyl>-5-O-(phenylmethyl)-α-D-ribofuranose diacetate 
• 132454-51-4 (2S,3R)-2,3-Bis-benzyloxymethyl-4-chloro-oxetane 
• 132454-56-9 (2S,3R,4S)-3,4-Bis-benzyloxymethyl-oxetane-2-carbonyl chloride 
• 146820-71-5 (2S,3R,4S)-3,4-Bis-benzyloxymethyl-oxetane-2-carboxylic acid 
• 103913-16-2 (-)-oxetanocin 
• 120293-59-6 α-Oxetanocin 
• 132454-55-8 (3S,4S,5S)-4,5-Bis-benzyloxymethyl-3-hydroxy-dihydro-furan-2-one 

Relevant academic research and scientific papers

Stereoselective cyclopropanation in the synthesis of 3'-deoxy-3'-C-hydroxymethyl-2',3'-methylene-uridine

The synthesis of the novel 2',3'-cyclopropane nucleoside 3'-deoxy-3'-C-hydroxymethyl-2',3'-methylene-uridine is described. Stereoselective construction of the cyclopropane ring was achieved via Simmons-Smith cyclopropanation of a benzyl protected silyl enol ether, which was itself derived from 1,2-O-isopropylidene-α-D-xylofuranose.

Synthesis and antiviral activity of novel isonucleoside analogs

A series of branched-chain sugar isonucleosides was synthesized and evaluated for antiviral activity against herpesviruses. The preparation of homochiral [3S-(3α,4β,5α)]-2-amino-1,9-dihydro-9-[tetrahydro-4,5- bis(hydroxymethyl)-3-furanyl]-6H-purin-6-one (

Syntheses and Biological Evaluations of 3'-Deoxy-3'-C-Branched-Chain-Substituted Nucleosides

Various 3'-deoxy-3'-C-(hydroxymethyl)-, 3'-deoxy-3'-C-(fluoromethyl)-, 3'-deoxy-3'-C-(azidomethyl)-, and 3'-deoxy-3'-C-(aminomethyl)-substituted nucleosides (total 12 compounds) have been synthesized and evaluated against L1210, P388, S-180, and CCRF-CEM

Purinyl tetrahydrofurans

Antiviral activity is exhibited by compounds having the formula STR1 and pharmaceutically acceptable salts thereof wherein R1 is a purine or pyrimidine base or an analog thereof and R2 and R3 are independently hydrogen, --

SYNTHESIS OF OXETANOCIN

A low yield synthesis of oxetanocin and its α-epimer by reaction of adenine with a protected 3-hydroxymethyl-2-chlorooxetane is described; attempts to synthesise other C-2'alkyl analogues of oxetanocin by analogous reactions indicate a limitation of this strategy for the synthesis of oxetane nucleosides.An intermediate for the synthesis of C-nucleoside analogues of oxetanocin is reported.