161459-80-9Relevant academic research and scientific papers
The chemistry of pseudomonic acid. 18. Heterocyclic replacement of the α,β-unsaturated ester: Synthesis, molecular modeling, and antibacterial activity
Brown, Pamela,Best, Desmond J.,Broom, Nigel J. P.,Cassels, Robert,O'Hanlon, Peter J.,Mitchell, Timothy J.,Osborne, Neal F.,Wilson, Jennifer M.
, p. 2563 - 2570 (2007/10/03)
The electronic requirements around the C1-C3 region of pseudomonic acid analogues were investigated. Synthetic routes were developed to access a range of compounds where the α,β-unsaturated ester moiety had been replaced by a 5-membered ring heterocycle.
Novel Synthesis of a Mixed Phosphonic Anhydride. A route to Carboxylic Acid Derivatives from a Methyl Ketone
Brown, Pamela,O'Hanlon, Peter J.
, p. 9619 - 9622 (2007/10/02)
Conversion of a methyl ketone to the kinetic enol phosphate followed by ozonolysis provides a novel synthesis of a mixed phosphonic anhydride.This can either be isolated, or reacted in situ with nucleophiles to afford the corresponding acid derivatives.
