161485-63-8

Basic information

• Product Name: 4-methoxy-N-[(E)-(4-methylphenyl)methylidene]aniline
• Synonyms: 4-Methoxy-N-[(E)-(4-methylphenyl)methylene]aniline; benzenamine, 4-methoxy-N-[(1E)-(4-methylphenyl)methylene]-; p-methylbenzylidene-(4-methoxyphenyl)-amine
• CAS NO: 161485-63-8
• Molecular Formula: C₁₅H₁₅NO
• Molecular Weight: 225.2857
• Mol File: 161485-63-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 365.8°C at 760 mmHg
• Flash Point: 142.1°C
• Density: 0.99g/cm³
• Vapor Pressure: 3.22E-05mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: 4-methoxy-N-[(E)-(4-methylphenyl)methylidene]aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-N-[(E)-(4-methylphenyl)methylidene]aniline(161485-63-8)
• EPA Substance Registry System: 4-methoxy-N-[(E)-(4-methylphenyl)methylidene]aniline(161485-63-8)

Safety Data

• Hazardous Substances Data: 161485-63-8(Hazardous Substances Data)

Upstream product

• 184017-91-2 4-methoxy-N-(4-methylbenzyl)aniline 
• 104-94-9 4-methoxy-aniline 
• 157142-48-8 2-amino-2-(4-methylphenyl)ethanol 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 2849-15-2 N,N'-Bis-(4-bromphenyl)-1,2-diphenyl-aethylendiamin 
• 1034152-01-6 methyl (2S,3S)-2-(9-anthrylmethoxy)-2-phenyl-3-(4-methoxyphenylamino)-3-p-tolylpropanoate 
• 132377-50-5 anti-1-(p-methoxyphenyl)-3-methyl-4-p-tolylazetidin-2-one 
• 132377-50-5 syn-1-(p-methoxyphenyl)-3-methyl-4-p-tolylazetidin-2-one 

Relevant articles and documents

Copper(ii) triflate catalyzed three-component reaction for the synthesis of 2,3-diarylquinoline derivatives using aryl amines, aryl aldehydes and styrene oxides

An efficient and expedient synthetic protocol is reported for the synthesis of 2,3-diarylquinoline derivatives from readily available aryl amines, aryl aldehydes and styrene oxides using 10 mol% copper(ii) triflate by employing three-component reaction. This approach involves the reaction between thein situgenerated imine (derived from the aryl amine and aryl aldehyde) and styrene oxide, which enables the formation of the desired products. The present method has several advantages such as high atom-economy, high regioselectivity, easy handling, consecutive one C-N and two C-C bond formation, shorter reaction time and broader substrate scope with good yields.

Iron-Catalyzed Reductive Ethylation of Imines with Ethanol

The borrowing hydrogen strategy has been applied to the ethylation of imines with an air-stable iron complex as precatalyst. This approach opens new perspectives in this area as it enables the synthesis of unsymmetric tertiary amines from readily available substrates and ethanol as a C2 building block. A variety of imines bearing electron-rich aryl or alkyl groups at the nitrogen atom could be efficiently reductively alkylated without the need for molecular hydrogen. The mechanism of this reaction, which shows complete selectivity for ethanol over other alcohols, has been studied experimentally and by means of DFT computations.

Ruthenium-catalyzed double-fold C-H tertiary alkoxycarbonylation of arenes using di-tert-butyl dicarbonate

An efficient ruthenium-catalyzed double-fold C-H alkoxycarbonylation of arenes was developed using di-tert-butyl dicarbonate as the tertiary esterification reagent, which leads to a direct route to valuable 2,6-dicarboxylated products. This journal is