1615-00-5

Usage

Uses

Used in Polymer Production:
2-Propenoic acid, 2-methyl-3-(3-nitrophenyl)is used as a monomer in the production of polymers for its ability to undergo polymerization reactions. The nitrophenyl group may impart specific properties to the resulting polymers, such as enhanced stability or reactivity, making them suitable for specialized applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Propenoic acid, 2-methyl-3-(3-nitrophenyl)is used as an intermediate in the synthesis of various drug compounds. Its unique structure allows for the development of new pharmaceuticals with potential therapeutic effects, particularly in the areas of inflammation, pain management, and other medical conditions.
Used in Agrochemicals:
2-Propenoic acid, 2-methyl-3-(3-nitrophenyl)is utilized in the agrochemical sector as a precursor for the development of new pesticides or herbicides. The nitro group in its structure can be reduced or further modified to create active ingredients with improved efficacy and selectivity in controlling pests and weeds.
Used as a Reagent in Organic Synthesis:
In organic synthesis, 2-Propenoic acid, 2-methyl-3-(3-nitrophenyl)serves as a versatile reagent for the preparation of a wide range of organic compounds. Its reactivity can be exploited in various chemical reactions, such as esterification, amidation, and condensation, to synthesize complex molecules for research and industrial purposes.
Used in Chemical Intermediates Production:
As an intermediate in the manufacture of other chemical compounds, 2-Propenoic acid, 2-methyl-3-(3-nitrophenyl)plays a crucial role in the synthesis of various specialty chemicals. Its unique structure and functional groups make it a valuable building block for the production of dyes, fragrances, and other精细化工产品.

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 123-62-6 propionic acid anhydride 
• 7796-34-1 tripropionyloxyborane 
• 516-05-2 methyl-propanedioic acid 
• 802294-64-0 propionic acid 

Downstream Products

• 39896-32-7 1-(3-nitrophenyl)propan-2-one 
• 41201-56-3 (+/-)-3-(3-amino-phenyl)-2-methyl-propionic acid 
• 103205-22-7 3t-(3-amino-phenyl)-2-methyl-acrylic acid 

Relevant academic research and scientific papers

Synthesis, characterization, antimicrobial, cytotoxic, DNA-interaction, molecular docking and DFT studies of novel di- and tri-organotin(IV) carboxylates using 3-(3-nitrophenyl)2-methylpropenoic acid

One diorganotin(IV) [n-Bu2SnL2] (1) and two triorganotin(IV) carboxylates [n-Bu3SnL] (2) and [Ph3SnL] (3) [L = 3-(3-nitrophenyl) 2-methylpropenoic acid] were synthesized and characterized by elemental analysis, FT-IR and NMR (1H, 13C) spectroscopies. The geometry of complexes and binding mode of ligand were worked out through FT-IR and NMR spectroscopies. The ligand coordinate with Sn via carboxylato oxygen in monodentate fashion leading to four coordinated?geometries around Sn center. The effectiveness of complexes towards their antimicrobial and cytotoxic potential was evaluated and a significant extent of antimicrobial potential was observed with a few exceptions. Molecular docking studies were performed for these complexes to check their interaction with DNA. Results from this study revealed that these compounds can bind favorably with cisplatin binding site and targeting the major groove of DNA. The complex-DNA interaction study was also performed through UV-Vis spectroscopic technique and viscosity measurement, and the observed experimental results were well matched with theoretical results. Computational vibrational analysis, frontier molecular orbital (FMO), natural bond orbitals (NBOs), linear and non-linear optical (NLO) properties of ligand and complexes 1-3 were calculated by density functional theory (DFT) and time-dependent DFT (TDDFT) using CAM-B3LYP/6-31G (d,p) level of theory to evaluate spectroscopic, structural parameters and reactivity patterns.

Discovery of a novel inhibitor of nitric oxide production with potential therapeutic effect on acute inflammation

Inflammation as a host's excessive immune response to stimulation, is involved in the development of numerous diseases. To discover novel anti-inflammatory agents and based on our previous synthetic work on marine natural product Chrysamide B, it and a series of derivatives were synthesized and evaluated for their anti-inflammatory activity on inhibition of LPS-induced NO production. Then the preliminary structure–activity relationships were conducted. Among them, Chrysamide B is the most potent anti-inflammatory agent with low cytotoxicity and strong inhibition on the production of NO (IC50 = 0.010 μM) and the activity of iNOS (IC50 = 0.082 μM) in LPS-stimulated RAW 264.7 cells. Primary studies suggested that the mechanism of action may be that it interfered the formation of active dimeric iNOS but not affected transcription and translation. Furthermore, its good performance of anti-inflammatory effect on LPS-induced multiple inflammatory cytokines production, carrageenan-induced paw edema, and endotoxin-induced septic mice, was observed. We believe that these findings would provide an idea for the further modification and research of these analogs in the future.

Sodium tetraborate-dibenzo-18-crown ether-6 complex as reagent in the synthesis of cinnamic acids from aromatic aldehydes and aliphatic carboxylic acids

Cinnamic acids have been prepared in 74-81% yields by a new synthesis from aromatic aldehydes and aliphatic carboxylic acids in the presence of anhydrous sodium tetraborate-dibenzo-18-crown ether-6 complex as reagent, 4-dimethylaminopyridine as activating agent, pyridine as base, and N-methyl-2-pyrolidinone as solvent, at reflux (180-190°C) for 10-12 hours.

A novel approach in cinnamic acid synthesis: Direct synthesis of cinnamic acids from aromatic aldehydes and aliphatic carboxylic acids in the presence of boron tribromide

Cinnamic acids have been prepared in moderate to high yields by a new direct synthesis using aromatic aldehydes and aliphatic carboxylic acids, in the presence of boron tribromide as reagent, 4-dimethylaminopyridine (4-DMAP) and pyridine (Py) as bases and N-methyl-2-pyrolidinone (NMP) as solvent, at reflux (180-190°C) for 8-12 hours.

New boron reagents for designed organic synthesis. 2 cinnamic acids synthesis in the presence of sodium tetramethoxyborate-lithium chloride

Cinnamic acids were prepared in good to high yields by Perkin reaction between aromatic aldehydes and aliphatic anhydrides in the presence of a boron compound, namely sodium tetramethoxyborate-lithium chloride, as a novel catalyst for this synthesis and N-methyl-pyrrolidin-2-one (NMP) as a solvent, at reflux (170-180°C) for 9-12 hours.

A new direct synthesis of cinnamic acids from aromatic aldehydes and aliphatic carboxylic acids in the presence of sodium borohydride

Cinnamic acids have been prepared in 59-86% yields by a new direct synthesis from aromatic aldehydes and aliphatic carboxylic acids in the presence of sodium borohydride and N-methyl-2-pyrrolidinone (NMP) as solvent, at reflux (185-190°C), for 9-12 hours. Without sodium borohydride, this reaction is not possible.