1615-06-1

Basic information

• Product Name: 1,3-DIHYDRO-2,1,3-BENZOTHIADIAZOLE 2,2-DIOXIDE
• Synonyms: 1,3-DIHYDRO-BENZO[1,2,5]THIADIAZOLE 2,2-DIOXIDE;1,3-DIHYDRO-2,1,3-BENZOTHIADIAZOLE 2,2-DIOXIDE;1H,3H-2,1,3-benzothiadiazole 2,2-dioxide;1,3-Dihydrobenzo[c][1,2,5]thiadiazole 2,2-dioxide
• CAS NO: 1615-06-1
• Molecular Formula: C₆H₆N₂O₂S
• Molecular Weight: 170.19
• Mol File: 1615-06-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 181-183 °C
• Boiling Point: 345.5 °C at 760 mmHg
• Flash Point: 162.8 °C
• Appearance: /
• Density: 1.452 g/cm³
• Vapor Pressure: 6.11E-05mmHg at 25°C
• Refractive Index: 1.613
• PKA: 5.62±0.20(Predicted)
• CAS DataBase Reference: 1,3-DIHYDRO-2,1,3-BENZOTHIADIAZOLE 2,2-DIOXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DIHYDRO-2,1,3-BENZOTHIADIAZOLE 2,2-DIOXIDE(1615-06-1)
• EPA Substance Registry System: 1,3-DIHYDRO-2,1,3-BENZOTHIADIAZOLE 2,2-DIOXIDE(1615-06-1)

Safety Data

• Hazardous Substances Data: 1615-06-1(Hazardous Substances Data)

Usage

General Description

1,3-Dihydro-2,1,3-benzothiadiazole 2,2-dioxide, also known as Cartap, is a chemical primarily used as an insecticide. It belongs to the chemical class of organic compounds and is known for its ability to control a wide range of insect pests in various crops such as rice, potatoes, and vegetables. It functions by disrupting the nervous system of the target insects, ultimately leading to paralysis and death. However, it is important to note that 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide is considered moderately toxic to mammals and can pose risks to human health and the environment if not used properly and according to safety guidelines.

InChI:InChI=1/C6H6N2O2S/c9-11(10)7-5-3-1-2-4-6(5)8-11/h1-4,7-8H

Upstream product

• 78973-88-3 1,3-dibenzyl-1H,3H-2,1,3-benzothiadiazole 2-oxide 
• 21443-66-3 N¹,N²-dibenzylbenzene-1,2-diamine 
• 1615-08-3 1,3-dibenzyl-1H,3H-2,1,3-benzothiadiazole 2,2-dioxide 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 31378-12-8 1,3-dimethyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1615-08-3 1,3-dibenzyl-1H,3H-2,1,3-benzothiadiazole 2,2-dioxide 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

Towards the inhibition of protein–protein interactions (PPIs) in STAT3: Insights into a new class of benzothiadiazole derivatives

Signal transducer and activator of transcription 3 (STAT3) is a validated anticancer target due to the relationship between its constitutive activation and malignant tumors. Through a virtual screening approach on the STAT3-SH2 domain, 5,6-dimethyl-1H,3H-2,1,3-benzothiadiazole-2,2-dioxide (1) was identified as a potential STAT3 inhibitor. Some benzothiadiazole derivatives were synthesized by employing a versatile methodology, and they were tested by an AlphaScreen-based assay. Among them, benzosulfamide 1 showed a significant activity with an IC50 = 15.8 ± 0.6 μM as a direct STAT3 inhibitor. Notably, we discovered that compound 1 was also able to interact with cysteine residues located around the SH2 domain. By applying mass spectrometry, liquid chromatography, NMR, and UV spectroscopy, an in-depth investigation was carried out, shedding light on its intriguing and unexpected mechanism of interaction.

BICYCLICALLY SUBSTITUTED URACILS AND THE USE THEREOF

The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.

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