16150-45-1

Usage

Uses

Used in Pharmaceutical Industry:
Diethyl cromoglycate is used as a prophylactic treatment for bronchial asthma. It functions by preventing the release of histamine, which is a key mediator in the inflammatory response associated with asthma. This helps in managing and maintaining the condition, providing relief from asthma symptoms.
Additionally, due to its anti-inflammatory properties, Diethyl cromoglycate may have potential applications in other areas of the pharmaceutical industry, such as treating allergies or other conditions involving histamine release. However, further research and development would be required to explore these possibilities.

InChI:InChI=1/C27H24O11/c1-3-33-26(31)22-11-16(29)24-18(7-5-9-20(24)37-22)35-13-15(28)14-36-19-8-6-10-21-25(19)17(30)12-23(38-21)27(32)34-4-2/h5-12,15,28H,3-4,13-14H2,1-2H3

Upstream product

• 15826-37-6 disodium cromoglicate 
• 75-03-6 ethyl iodide 
• 64-17-5 ethanol 
• 50521-64-7 5-hydroxy-4-oxo-4H-benzopyran-2-carboxylic acid ethyl ester 
• 106-89-8 epichlorohydrin 
• 96-21-9 1,3-dibromo-2-hydroxypropane 
• 699-83-2 2,6-dihydroxylacetophenone 

Downstream Products

• 15826-37-6 disodium cromoglicate 
• 110816-78-9 2-(L-lysyloxy)-1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane dihydrochloride 

Relevant academic research and scientific papers

Preparation method of diethyl cromoglycate and sodium cromoglycate

The invention relates to the technical field of medicines, in particular to a preparation method of diethyl cromoglycate and sodium cromoglycate. The preparation method comprises the following steps:reacting 2, 6-dihydroxy acetophenone with diethyl oxalate to obtain 7-hydroxy-4-oxo-4H-benzopyran-2-carboxylic acid ethyl ester, and then reacting with 1, 3-dibromo-2-propanol(or epoxy chloropropane)to prepare diethyl cromoglycinate, because one phenolic hydroxyl group in the 7-hydroxy-4-oxo-4H-benzopyran-2-carboxylic acid ethyl ester molecule is protected, cutting off the source of polymolecularpolycondensation reaction, wherein two reaction sites of 1, 3-dibromo-2-propanol(or epoxy chloropropane) need to participate in the reaction, and obtaining the unique product diethyl cromoglycate through the reaction. Therefore, the yield of the diethyl cromoglycate is very high.

CROMOLYN ESTERS AND USES THEREOF

Described herein are compounds and methods of treating or imaging a disease or disorder, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, ischemic stroke, and prion disease, comprising administering a therapeutically effective amoun

MACROPHAGES/MICROGLIA IN NEURO-INFLAMMATION ASSOCIATED WITH NEURODEGENERATIVE DISEASES

Described herein are methods of treating neuron inflammation conditions, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, ischemic stroke, and prion disease, comprising administering a therapeutically effective amount of cromol

CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT

Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula (I), o