161511-08-6

Basic information

• Product Name: (4aR,4bS,6aS,7S,9aS,9bS)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid
• Synonyms: (4aR,4bS,6aS,7S,9aS,9bS)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid
• CAS NO: 161511-08-6
• Molecular Weight: 319.444
• Mol File: 161511-08-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4aR,4bS,6aS,7S,9aS,9bS)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (4aR,4bS,6aS,7S,9aS,9bS)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid(161511-08-6)
• EPA Substance Registry System: (4aR,4bS,6aS,7S,9aS,9bS)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid(161511-08-6)

Safety Data

• Hazardous Substances Data: 161511-08-6(Hazardous Substances Data)

Upstream product

• 103335-54-2 (4aR,4bS,6aS,7S,9aS,9bS)-4a,6a-dimethyl-2-oxo-2,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid 
• 302-97-6 androst-4-en-3-one-17β-carboxylic acid 

Relevant articles and documents

A 3-carbonyl-4-nitrogen mixed male steroid -17 β method for the preparation of carboxylic acid

The invention belongs to the field of organic chemistry and provides a preparation method for 3-carbonyl-4-aza-androstane-17 beta carboxylic acid. The method comprises the steps: (1) dissolving 3-carbonyl-4-aza-5-androstane-17 beta carboxylic acid in alkaline water, adding a palladium-carbon catalyst, and introducing hydrogen for performing hydrogenation; (2) filtering after the hydrogenation until the pH value of filtrate obtained by filtering is 3-5, filtering by a centrifugal machine to obtain a filter cake, washing the filter cake with water until eluate is neutral, and spinning-drying the filter cake so as to obtain a crude 3-carbonyl-4-aza-androstane-17 beta carboxylic acid product; and (3) pulping the crude 3-carbonyl-4-aza-androstane-17 beta carboxylic acid product with methyl alcohol, filtering by the centrifugal machine to obtain a filter cake, washing the filter cake with the methyl alcohol, spinning-drying, and drying so as to obtain a fine 3-carbonyl-4-aza-androstane-17 beta carboxylic acid product. Organic solvents are not used in the method provided by the invention, the economy and environment protection performances are realized, and the post-treatment is easy; the reaction is performed under an alkaline condition, the catalytic activity and the selectivity (the isomer ratio is low) of palladium-carbon are high, and the yield is high; by using the method, products with the relatively purity and relatively high yield can be obtained.