161518-61-2Relevant academic research and scientific papers
Synthesis of carbon-14 labeled Taxolo (paclitaxel)
Walker,Swigor,Kant,Schroeder
, p. 973 - 980 (1994)
Reductive cleavage of the C13 side chain of Taxolo (1, paclitaxel) followed by regioselective silylation gave 7-triethylsilylbaccatin III (4). 3-O-Triethylsilylation of 5 and subsequent reaction with benzoyl chloride-C7-14C gave azetidinone 7. Coupling of 4 and 7 followed by deprotection gave 1.26 g of Taxol-N3'14C (11) having a specific activity of 26.5 mCi/mmol and a radiochemical purity of 95%.
