Journal of labelled compounds and radiopharmaceuticals p. 973 - 980 (1994)
Update date:2022-09-26
Topics:
Walker
Swigor
Kant
Schroeder
Reductive cleavage of the C13 side chain of Taxolo (1, paclitaxel) followed by regioselective silylation gave 7-triethylsilylbaccatin III (4). 3-O-Triethylsilylation of 5 and subsequent reaction with benzoyl chloride-C7-14C gave azetidinone 7. Coupling of 4 and 7 followed by deprotection gave 1.26 g of Taxol-N3'14C (11) having a specific activity of 26.5 mCi/mmol and a radiochemical purity of 95%.
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