1615246-46-2Relevant academic research and scientific papers
Microwave assisted tandem heck-sonogashira reactions of N,N-Di-Boc-protected 6-amino-5-iodo-2-methyl pyrimidin-4-ol in an efficient approach to functionalized pyrido[2,3-d]pyrimidines
Liu, Yang,Jin, Shiyu,Wang, Zi,Song, Linhua,Hu, Youhong
supporting information, p. 3524 - 3527 (2014/07/21)
A microwave assisted tandem Heck-Sonogashira cross-coupling reaction between 6-N,N-di-Boc-amino-5-iodo-2-methyl pyrimidin-4-ol and various aryl alkynyl substrates has been developed. This process generates novel 5-enynyl substituted pyrimidines, which can be transformed to novel functionalized pyrido[2,3-d]pyrimidines by way of a silver catalyzed cyclization reaction.
