161531-30-2Relevant academic research and scientific papers
Synthesis of Unsymmetrically 4-Substituted 2,2'-Bipyridines
Kelli-Basetti, Bernadette M.,Krodkiewska, Irena,Sasse, Wolfgang H. F.,Savage, G. Paul,Simpson, Gregory W.
, p. 327 - 330 (2007/10/02)
Pyridin-2-nitrile oxide was generated in situ and reacted with 2-substituted but-1-ene-4-ols to give 5-substituted 5-(2-hydroxyethyl)-3-(pyrid-2-yl)-Δ2-isoxazolines.The isoxazolines were reductively ring-opened with LiAlH4 to give 2-(3-substituted-1-amino-3,5-dihydroxypentyl)-pyridines, which were subjected to Dess-Martin oxidation with concomitant dehydration to give 4-substituted 2,2'-bipyridines.
