1772-01-6

Basic information

• Product Name: N'-HYDROXYPYRIDINE-2-CARBOXIMIDAMIDE
• Synonyms: PYRIDINE-2-ACETAMIDE OXIME;PYRIDINE-2-CARBOXAMIDE OXIME;N-HYDROXYPYRIDINE-2-CARBOXAMIDINE;N'-HYDROXYPYRIDINE-2-CARBOXIMIDAMIDE;RARECHEM BG FB 0127;n-hydroxy-2-pyridinecarboximidamid;picolinamideoxime;picolinamidoxime
• CAS NO: 1772-01-6
• Molecular Formula: C₆H₇N₃O
• Molecular Weight: 137.14
• Product Categories: Heterocyclic Compounds
• Mol File: 1772-01-6.mol
• Article Data: 55

Chemical Properties

• Melting Point: 120-124 °C(lit.)
• Boiling Point: 278℃
• Flash Point: 122℃
• Appearance: /
• Density: 1.31
• Refractive Index: 1.6910 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 13.61±0.50(Predicted)
• CAS DataBase Reference: N'-HYDROXYPYRIDINE-2-CARBOXIMIDAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N'-HYDROXYPYRIDINE-2-CARBOXIMIDAMIDE(1772-01-6)
• EPA Substance Registry System: N'-HYDROXYPYRIDINE-2-CARBOXIMIDAMIDE(1772-01-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: TJ4310000
• HazardClass: IRRITANT
• Hazardous Substances Data: 1772-01-6(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white crystal or powder

Uses

2-Pyridylamide oxime is a synthetic intermediate useful for pharmaceutical synthesis.

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 873-69-8 2-pyridinealdoxime 
• 100-70-9 2-Cyanopyridine 
• 749932-24-9 N-chloroacetoxy-pyridine-2-carboximidic acid amide 
• 2739-97-1 pyridine-2-acetonitrile 

Downstream Products

• 69716-28-5 (Z)-picolinaldehyde (α)-chloro-oxime 
• 453567-16-3 5-(3-Cyano-5-trifluoromethoxyphenyl)-3-(pyridin-2-yl)-1,2,4-oxadiazole 
• 327056-43-9 3-(pyridin-2-yl)-5-(2-aminophenyl)-1,2,4-oxadiazole 
• 425619-08-5 C₁₃H₁₁N₃O₂ 
• 90002-06-5 5-(chloromethyl)-3-(pyridin-2-yl)-1,2,4-oxadiazole 
• 13389-61-2 3-(2’-pyridyl)-5-phenyl-1,2,4-oxadiazole 
• 1448510-47-1 3-phenyl-5-(2-pyridyl)-1,2,4-oxadiazole-4-oxide 
• 58598-96-2 5-(2’-pyridyl)-3-phenyl-1,2,4-oxadiazole 
• 1338690-08-6 tert-butyl-(3-(pyridine-2-yl)-1,2,4-oxadiazol-5-yl)methylcarbamate 
• 10350-68-2 2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridine 
• 404849-00-9 5-cyclohexyl-3-(pyridine-2-yl)-1,2,4-oxadiazole 
• 1452-77-3 pyridine-2-carboxylic acid amide 

Relevant articles and documents

Novel O-acylated amidoximes and substituted 1,2,4-oxadiazoles synthesised from (+)-ketopinic acid possessing potent virus-inhibiting activity against phylogenetically distinct influenza A viruses

This article describes the synthesis and antiviral activity evaluation of new substituted 1,2,4-oxadiazoles containing a bicyclic substituent at position 5 of the heterocycle and O-acylated amidoximes as precursors for their synthesis. New compounds were

Olefination via Cu-Mediated Dehydroacylation of Unstrained Ketones

The dehydroacylation of ketones to olefins is realized under mild conditions, which exhibits a unique reaction pathway involving aromatization-driven C-C cleavage to remove the acyl moiety, followed by Cu-mediated oxidative elimination to form an alkene between the α and β carbons. The newly adopted N′-methylpicolinohydrazonamide (MPHA) reagent is key to enable efficient cleavage of ketone C-C bonds at room temperature. Diverse alkyl- and aryl-substituted olefins, dienes, and special alkenes are generated with broad functional group tolerance. Strategic applications of this method are also demonstrated.

An Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-ones by Using Recyclable Wang Resin Supported Sulfonic Acid Catalyst

An efficient synthesis of 2-substituted Quinazolin-4(3H)-ones has been developed from isatoic anhydride with various amidoximes by using a recyclable polymer-supported sulphonic acid catalyst. Excellent functional group compatibility and high yields are the important features of this protocol.