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16154-71-5

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16154-71-5 Usage

General Description

2-Methyl-4-(4-methylpiperazin-1-yl)aniline is a chemical compound with the molecular formula C12H18N2. It is an organic compound belonging to the class of anilines, which are aromatic amines derived from benzene. This particular compound contains a piperazine ring, a six-membered heterocyclic ring containing two nitrogen atoms, and an aniline group, which consists of a benzene ring attached to an amino group. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-METHYL-4-(4-METHYLPIPERAZIN-1-YL)ANILINE has potential applications in research and development, as well as in the manufacturing of various products. Its properties and uses make it an important chemical in the field of chemistry and industry.

Check Digit Verification of cas no

The CAS Registry Mumber 16154-71-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,1,5 and 4 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 16154-71:
(7*1)+(6*6)+(5*1)+(4*5)+(3*4)+(2*7)+(1*1)=95
95 % 10 = 5
So 16154-71-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H19N3/c1-10-9-11(3-4-12(10)13)15-7-5-14(2)6-8-15/h3-4,9H,5-8,13H2,1-2H3/p+1

16154-71-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Methyl-4-(4-methyl-1-piperazinyl)aniline

1.2 Other means of identification

Product number -
Other names 2-methyl-4-(4-methylpiperazin-1-yl)aniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16154-71-5 SDS

16154-71-5Downstream Products

16154-71-5Relevant articles and documents

INDOLINONE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS

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, (2020/05/15)

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring C, X1, X2, L1, R1, R2, R3, R4, R5, R6, R7, m and n are as defined herein, which are useful as MAP4K1 inhibitors, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by MAP4K1.

Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRα) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs)

Lu, Yanli,Mao, Fei,Li, Xiaokang,Zheng, Xinyu,Wang, Manjiong,Xu, Qing,Zhu, Jin,Li, Jian

supporting information, p. 5099 - 5119 (2017/06/28)

Stem cell factor receptor (c-KIT) and platelet derived growth factor receptor alpha (PDGFRα) kinases play an important role in gastrointestinal stromal tumors (GISTs). Here, we have discovered an c-KIT/PDGFRα dual inhibitor, compound 31, with single-digit nanomolar potency against c-KIT and PDGFRα. Compared to Imatinib (1), 31 showed better antiproliferative efficacy against various TEL-c-KIT/PDGFRα-BaF3 isogenic cells, including three 1-resistant BaF3 cell lines, as well as against GIST-T1 and GIST-882 cell lines. Furthermore, compound 31 showed a good KinomeScan selectivity (468 kinases) (S score (1) = 0.01 at 1 μM concentration), good metabolic stability in liver microsomes, and no hERG inhibitory activity. It was worth noting that 31 inhibited GIST-T1 tumor growth (TGI = 81.5%) and even the BaF3-TEL-cKIT-T670I tumor progression (TGI = 41.9%, 1-resistant GISTs) at a dosage of 100 mg/kg/day without exhibiting apparent toxicity.

2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES

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Page/Page column 73, (2008/06/13)

The present invention relates to pyrimidine or pyridine carboxamides or pharmaceutically-acceptable salts thereof. Also included is a method of treatment of inflammation, inhibition of T cell activation and proliferation, arthritis, rheumatoid arthritis,

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