446-33-3

Usage

Chemical Properties

colorless to light yellow liqui

InChI:InChI=1/C7H6FNO2/c1-5-4-6(8)2-3-7(5)9(10)11/h2-4H,1H3

Upstream product

• 352-70-5 m-Fluorotoluene 
• 7697-37-2 nitric acid 
• 446-35-5 2,4-Difluoronitrobenzene 
• 591-09-3 nitro acetate 

Downstream Products

• 25234-41-7 N,N-Dimethyl-N'-(3-methyl-4-nitro-phenyl)-propane-1,3-diamine 
• 102791-96-8 1-(3-methyl-4-nitrophenyl)-1H-1,2,4-triazole 
• 102791-93-5 2-Methyl-1-(3-methyl-4-nitro-phenyl)-1H-imidazole 
• 102791-95-7 5-Methyl-1-(3-methyl-4-nitro-phenyl)-1H-imidazole 
• 102791-94-6 5-(4-methylimidazol-1-yl)-2-nitrotoluene 
• 90556-89-1 5-(dimethylamino)-2-nitrotoluene 
• 111566-79-1 4-Iodo-2-methyl-1-(3-methyl-4-nitrophenyl)imidazole 
• 91527-90-1 3-methyl-4-nitrophenylhydrazine 
• 82420-35-7 2-(bromomethyl)-4-fluoro-1-nitrobenzene 
• 147285-87-8 4-fluoro-2-methyl-6-nitrophenylamine 
• 102792-14-3 2-(3-Methyl-4-nitro-phenyl)-2H-tetrazole 
• 301672-88-8 4-(3-methyl-4-nitrophenyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 5367-32-8 5-methoxy-2-nitrotoluene 
• 357210-21-0 9-(3'-methyl-4'-nitrophenyl)-9H-pyrido[3,4-b]indole 

Relevant academic research and scientific papers

Preparation method of 2- bromo -4- fluoro -6- methyl phenol (by machine translation)

2 - (,) The process for preparing .2 -methylnitrobenzene, (:) by subjecting 1 fluorine - 2 2-methylnitrobenzene prepared in step (:) to a reduction reaction 4 - to prepare; fluorine - 2 2-methylphenol. 2. The method comprises the following steps :) of nitrosation reaction 1 (4 -) diazo hydrolysis. 4 - g - 2 2-methylphenol prepared by the following steps: The process of the present invention, is simple 3% by diazotization reaction: to prepare 3 the 2 fluorine - 2 2-methylphenol obtained in step (4 -) by means of a reduction reaction step (4 -) to form 4 - fluorine. 2 2 (4 2 -)-methylphenol prepared by the same step as a process. for the preparation of fine chemical products by 2 - means of the bromination reaction step of the preparation, method as shown in the following step (. a).]) The method comprises the following steps: (a)) diazo reaction : (by machine translation)

A short synthesis of 9-fluoroellipticine from 5-fluoroindole?

A synthesis of 9-fluoroellipticine (1c) from 5-fluoroindole (6) is described that features the regioselective lithiation of 5-fluoro-1-(phenylsulfonyl)indole (7) followed by chemoselective acylation of 3,4-pyridinedicarboxylic anhydride. Subsequent cyclization of keto acid 9 to keto lactam 10 with acetic anhydride and sequential treatment of 10 with methyllithium and sodium borohydride affords 9-fluoroellipticine.

Bicyclic And Tricyclic Compounds As KAT II Inhibitors

Compounds of Formula X: wherein A, X, Y, Z, R5, R6a, and R6b are as defined herein, and pharmaceutically acceptable salts thereof, are described as useful for the treatment of cognitive deficits associated with schizophrenia and other neurodegenerative and/or neurological disorders in mammals, including humans.

Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia

In position 7 substituted indenyl-3-acetic acid derivatives and pharmaceutically acceptable salts and amides thereof have anti-neoplastic activity.

Bis(dealkoxycarbonylation) of nitroarylmalonates: A facile entry to alkylated nitroaromatics

A simple approach to alkylated nitroaromatics from substituted nitroaryl malonic esters by double decarboxylation is detailed.

A novel method for the nitration of simple aromatic compounds

Simple aromatic compounds such as benzene, alkylbenzenes, halogenobenzenes, and some disubstituted benzenes are nitrated in excellent yields with high regioselectivity under mild conditions using zeolite β as a catalyst and a stoichiometric quantity of nitric acid and acetic anhydride. The zeolite can be recycled, and the only byproduct is acetic acid, which can be separated easily from the nitration product by distillation; the process is inexpensive and represents an attractive method for the clean synthesis of a range of nitroaromatic compounds. For example, nitration of toluene gives a quantitative yield of mononitrotoluenes, of which 79% is 4-nitrotoluene; fluorobenzene gives a quantitative yield of mononitro compounds, of which 94% is 4-nitrofluorobenzene; and 2-fluorotoluene gives a 96% yield of mononitro products, of which 90% is the 5-nitro isomer and 10% is the 4-nitro isomer.

Quinolonecarboxylic acids for control of bacterial diseases in plants

Quinolonecarboxylic acids, such as 6-fluoro-1,4-dihydro-8-methyl-4-oxo-1-(2,2,2-trifluoroethyl)-3-quinolonecarboxylic acid, ethyl ester, useful for control of certain bacterial plant diseases, such as fire blight of apple, pear and soft rot of potato, and gall formation on herbaceous and woody plants.

Indenylacetic acid compounds

4, 5, 6 or 7 Aryl substituted indenyl acetic acids and pharmaceutically acceptable salts, amides and esters thereof. The 4, 5, 6 or 7 aryl substituted indenyl acetic acids have anti-inflammatory, anti-pyretic and analgesic activity. The invention also includes methods for the preparation of these compounds, pharmaceutical compositions and methods of treating inflammation by administering these particular compounds to patients.