161554-75-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 1026372-78-0 (2S,3S,4S)-3-Benzylamino-2-((R)-1-hydroxy-ethyl)-4-trityloxy-pentanoic acid tert-butyl ester 
• 76-83-5 trityl chloride 
• 14856-79-2 N-benzyl(trimethylsilyl)amine 
• 123077-64-5 (S)-2-trityloxypropanal 
• 123077-62-3 ethyl (S)-2-(trityloxy)propionate 
• 194367-52-7 (3S,4S)-3-Benzylamino-4-trityloxy-pentanoic acid tert-butyl ester 
• 161554-88-7 (E)-(S)-4-Trityloxy-pent-2-enoic acid tert-butyl ester 

Downstream Products

• 161554-76-3 (3S,4S)-1-Benzyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-((S)-1-trityloxy-ethyl)-azetidin-2-one 
• 194367-29-8 (3S,4S)-1-Benzyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-((S)-1-hydroxy-ethyl)-azetidin-2-one 

Relevant academic research and scientific papers

Highly Diastereoselective Conjugate Addition of Lithium Dialkylamides to α,β-Unsaturated Esters Having a Chiral Center at the γ-Position

The conjugate addition of lithium amides 2 to tert-butyl 4-(OR)-substituted-2-pentenoates 1 produced a mixture of the syn- and anrt-amino esters (3 and 4) in high yields. Sterically bulky OR groups, such as trityloxy and tert-butyldiphenylsilyloxy, gave t

Highly stereocontrolled and concise asymmetric synthesis of the β-lactam framework via a TCC method

The conjugate addition of LSA 1 to t-butyl (4S)-4-(trityl)oxy-2-pentenoate 2d followed by aldol condensation with acetaldehyde produces a key intermediate 3 to β-lactam derivatives as a single diastereoisomer in 77% yield.