161561-84-8

Basic information

• Product Name: Carbamic acid, [2-amino-1-(methoxymethyl)-2-oxoethyl]-, 1,1-dimethylethyl
• Synonyms: Carbamic acid, [2-amino-1-(methoxymethyl)-2-oxoethyl]-, 1,1-dimethylethyl
• CAS NO: 161561-84-8
• Molecular Formula: C9H18N2O4
• Molecular Weight: 218.25022
• Product Categories: N-BOC
• Mol File: 161561-84-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [2-amino-1-(methoxymethyl)-2-oxoethyl]-, 1,1-dimethylethyl(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-amino-1-(methoxymethyl)-2-oxoethyl]-, 1,1-dimethylethyl(161561-84-8)
• EPA Substance Registry System: Carbamic acid, [2-amino-1-(methoxymethyl)-2-oxoethyl]-, 1,1-dimethylethyl(161561-84-8)

Safety Data

• Hazardous Substances Data: 161561-84-8(Hazardous Substances Data)

Upstream product

• 134167-07-0 (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-methoxypropanoate 
• 2766-43-0 N-tert-butyloxycarbonyl-L-serine methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 183793-47-7 (S)-2-tert-butoxycarbonylamino-3-methoxy-propionic acid benzyl ester 
• 51293-47-1 N-tert-butoxycarbonyl-(S)-O-methyl-serin 

Relevant articles and documents

Bacterial preparation of enantiopure unactivated aziridine-2-carboxamides and their transformation into enantiopure nonnatural amino acids and vic-diamines

Enantiopure (1R,2S)-1-benzyl- and 1-arylaziridine-2-carboxamides were obtained by kinetic resolution of their racemates by Rhodococcus rhodochrous IFO 15564 catalyzed hydrolysis. Several regio- and enantioselective nucleophilic ring openings of (1R,2S)-1-benzylaziridine-2-carboxamide or its LAH-reduced product led to a series of enantiopure products, such as O-methyl-L-serine and some vicinal diamines.

CYSTEINE PROTEASE INHIBITORS

A compound of the formula (II) wherein one of R1 and R2 is halo and the other is H or halo; R3 is C1-C4 straight or branched chain, optionally fluorinated, alkyl; R4 is H; or R3 together with R4 and the adjoining backbone carbon defines: a spiro-C5-C7 cycloalkyl, optionally substituted with 1 to 3 substituents selected from halo, hydroxyl, C1-C4 alkyl or C1-C4 haloalkyl; or optionally bridged with a methylene group; or a C4-C6 saturated heterocycle having a hetero atom selected from O, NRa, S, S(=O)2 ; where Ra is H, C1-C4 alkyl or CH3C(=O); R5 is independently selected from H or methyl; E is -C(=O)-, -S(=O)m-, -NR5S(=O)m-, -NR5C(=O)-, -OC(=O)-, R6 is a stable, optionally substituted, monocyclic or bicyclic, carbocycle or hetorocycle; m is independently 0,1 or 2; are inhibitors of cathepsin K and useful in the treatment or prophylaxis of osteoporosis.

Synthetic studies towards keramamide F

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