1615652-99-7

Upstream product

• 100-52-7 benzaldehyde 
• 76464-99-8 N-benzyl-2-iodoaniline 
• 7099-91-4 p-methoxybenzoylformic acid 
• 324738-51-4 2′-N-benzylaminophenylacetylene 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 1615653-11-6 1-benzyl-3-diethoxyphosphoryloxy-3-(4-methoxyphenyl)-4-methylene-3,4-dihydro-2-quinolone 
• 1615653-25-2 C₂₈H₃₀NO₆P 
• 1615653-31-0 1-benzyl-4-diethoxyphosphoryloxymethyl-3-(4-methoxyphenyl)-2-quinolone 

Relevant academic research and scientific papers

Intramolecular cyclization of alkynyl α-ketoanilide utilizing [1,2]-phospha-brook rearrangement catalyzed by phosphazene base

A novel catalytic cyclization reaction of alkynyl α-ketoanilide was developed by utilizing the [1,2]-phospha-Brook rearrangement. This reaction involves the generation of an amide enolate via the umpolung process, that is the addition of dialkyl phosphite to a keto moiety followed by the [1,2]-phospha-Brook rearrangement, and the subsequent intramolecular addition of the enolate to an alkyne to afford 3,4-dihydro-2-quinolone derivatives. Under high-temperature reaction conditions, further rearrangement of the allylic phosphate moiety occurs to provide 2-quinolone derivatives.