1615685-40-9

Upstream product

• 1344109-47-2 2-bromo-4-(pyrrol-1-yl)benzyl alcohol 
• 1344109-43-8 2-bromo-4-(pyrrol-1-yl)benzoic acid methyl ester 
• 98545-64-3 methyl-2-bromo-4-aminobenzoate 
• 100959-22-6 methyl 2-bromo-4-nitrobenzoate 
• 16426-64-5 2-bromo-4-nitrobenzoic acid 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 856794-72-4 2-bromo-4-nitrobenzoyl chloride 
• 1615685-37-4 2-(methoxymethyl)-5-(3-benzoylpyrrol-1-yl)benzyl acetate 
• 1615685-36-3 2-(methoxymethyl)-5-(pyrrol-1-yl)benzyl acetate 
• 1615685-35-2 2-(methoxymethyl)-5-(pyrrol-1-yl)benzyl alcohol 
• 1615685-34-1 2-(methoxymethyl)-5-(pyrrol-1-yl)benzaldehyde 
• 1615685-33-0 1-(3-bromo-4-(methoxymethyl)phenyl)pyrrole 

Relevant academic research and scientific papers

Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosoma brucei

Human African trypanosomiasis is a fatal parasitic infection caused by the protozoan Trypanosoma brucei. The development of novel antitrypanosomal agents is urgently needed. Here we report the synthesis and structure-activity relationship of a new class of benzoxaboroles as antitrypanosomal agents. These compounds showed antiparasitic IC50 values ranging from 4.02 to 0.03 μg/mL and satisfactory cytotoxicity profile. Three of the lead compounds were demonstrated to cure the parasitic infection in a murine acute infection model. The structure-activity relationship of the pyrrolobenzoxaboroles are also discussed.