1615687-63-2

Basic information

• Product Name: 14-methyl-5-oxo-5,7,8,13,13b,14-hexahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-3-yl(3-methoxyphenyl)carbamate
• Synonyms: 14-methyl-5-oxo-5,7,8,13,13b,14-hexahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-3-yl(3-methoxyphenyl)carbamate
• CAS NO: 1615687-63-2
• Molecular Weight: 468.512
• Mol File: 1615687-63-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 14-methyl-5-oxo-5,7,8,13,13b,14-hexahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-3-yl(3-methoxyphenyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 14-methyl-5-oxo-5,7,8,13,13b,14-hexahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-3-yl(3-methoxyphenyl)carbamate(1615687-63-2)
• EPA Substance Registry System: 14-methyl-5-oxo-5,7,8,13,13b,14-hexahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-3-yl(3-methoxyphenyl)carbamate(1615687-63-2)

Safety Data

• Hazardous Substances Data: 1615687-63-2(Hazardous Substances Data)

Upstream product

• 4894-26-2 3,4-dihydro-β-carboline 
• 6502-82-5 N_b-formyltryptamine 
• 1355077-52-9 3-(benzyloxy)-14-methyl-7,8,13b,14-tetrahydroindolo[20,30:3,4]pyrido[2,1-b]quinazolin-5(13H)-one 
• 18908-07-1 3-methoxyphenyl isocyanate 
• 1615687-56-3 3-(benzyloxy)-14-methyl-7,8,13b,14-tetrahydroindolo[20,30:3,4]pyrido[2,1-b]quinazolin-5(13H)-one 
• 622829-44-1 benzyl 5-(benzyloxy)-2-((ethoxycarbonyl)amino)benzoate 
• 394-31-0 2-amino-5-hydroxybenzoic acid 
• 104356-42-5 5-(benzyloxy)-2-((ethoxycarbonyl)amino)benzoic acid 

Relevant articles and documents

Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine

Two sets of carbamates based on the natural alkaloid evodiamine were desined, synthesized and evaluated as potential butyrylcholinesterase inhibitors. Althouh a set of carbamates of 3-hydroxyevodiamine (10a-f) is inactive both at AChE and BChE, carbamates of 5-deoxo-3-hydroxyevodiamine (11a-f) exhibit much better potency with selectivity toward BChE. The heptyl carbamate of 5-deoxo-3-hydroxyevodiamine (11c) shows the best potency with an IC50 value of 77 nM and very ood selectivity over AChE. ORAC and cell-based assays indicate 11c owns pronounced antioxidant properties with 1.75 Trolox equivalents and stron neuroprotection even from 1 μM onwards. These combined activities miht enable compound 11c to be a potential candidate for treatment of Alzheimer's disease.