104356-42-5Relevant articles and documents
Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and h H3 receptor antagonists
Darras, Fouad H.,Pockes, Steffen,Huang, Guozheng,Wehle, Sarah,Strasser, Andrea,Wittmann, Hans-Joachim,Nimczick, Martin,Sotriffer, Christoph A.,Decker, Michael
, p. 225 - 242 (2014)
Combination of AChE inhibiting and histamine H3 receptor antagonizing properties in a single molecule might show synergistic effects to improve cognitive deficits in Alzheimer's disease, since both pharmacological actions are able to enhance ch
Approach to the synthesis of (+)-ifforestine. Model studies directed at the tetracyclic framework
Roos, Gregory H. P.,Dastlik, Kim A.
, p. 2023 - 2044 (2007/10/03)
In order to design an effective asymmetric synthesis of (+)-ifforestine, model approaches to the construction of the tetracyclic ring system have been investigated. These studies have identified two key synthons, a functionalized isatoic anhydride and a p