1616087-92-3

Basic information

• Product Name: N-[2,3,4,5-tetrafluorobenzoyl]-S-methyl-S-phenylsulfoximine
• CAS NO: 1616087-92-3
• Molecular Weight: 331.291
• Mol File: 1616087-92-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[2,3,4,5-tetrafluorobenzoyl]-S-methyl-S-phenylsulfoximine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2,3,4,5-tetrafluorobenzoyl]-S-methyl-S-phenylsulfoximine(1616087-92-3)
• EPA Substance Registry System: N-[2,3,4,5-tetrafluorobenzoyl]-S-methyl-S-phenylsulfoximine(1616087-92-3)

Safety Data

• Hazardous Substances Data: 1616087-92-3(Hazardous Substances Data)

Upstream product

• 1201-31-6 2,3,4,5-tetrafluorobenzoic acid 
• 4381-25-3 S-methyl-S-phenylsulfoximine 
• 1193-82-4 racemic methyl phenyl sulfoxide 

Downstream Products

• 1616088-11-9 N-[(E)-2-(2-(phenylsulfonyl)vinyl)tetrafluorobenzoyl]-S-methyl-S-phenylsulfoximine 
• 1616088-10-8 N-[(E)-2-(3-ethoxy-3-oxoprop-1-en-1-yl)tetrafluorobenzoyl]-S-methyl-S-phenylsulfoximine 
• 1616088-17-5 C₁₉H₁₇F₄NO₄S 

Relevant articles and documents

Sulfoximine-directed ruthenium-catalyzed ortho -C-H Alkenylation of (Hetero)Arenes: Synthesis of EP3 receptor antagonist analogue

The reusable sulfoximine directing-group-assisted Ru(II)-catalyzed chemo- and regioselective ortho-C-H alkenylation of arenes and heteroarenes with acrylates and α,β-unsaturated ketones/vinyl sulfone is shown. The N-aroyl sulfoximine undergoes annulation with diphenylacetylene, delivering isoquinolinones and methyl phenyl sulfoxide. The present protocol is successfully employed for the synthesis of the EP3 receptor antagonist analogue.