161610-13-5

Basic information

• Product Name: 2-Fluoro-4'-hydroxy-3',4',5',6'-tetrahydro-2'H[3,4']bipyridinyl-1'-carboxylic acid
• Synonyms: 2-Fluoro-4'-hydroxy-3',4',5',6'-tetrahydro-2'H[3,4']bipyridinyl-1'-carboxylic acid;4-(2-Fluoro-3-pyridinyl)-4-hydroxy-1-piperidinecarboxylic acid phenylmethyl ester;BENZYL 4-(2-FLUOROPYRIDIN-3-YL)-4-HYDROXYPIPERIDINE-1-CARBOXYLATE
• CAS NO: 161610-13-5
• Molecular Formula: C₁₈H₁₉FN₂O₃
• Molecular Weight: 330.3534632
• Mol File: 161610-13-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.306
• CAS DataBase Reference: 2-Fluoro-4'-hydroxy-3',4',5',6'-tetrahydro-2'H[3,4']bipyridinyl-1'-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4'-hydroxy-3',4',5',6'-tetrahydro-2'H[3,4']bipyridinyl-1'-carboxylic acid(161610-13-5)
• EPA Substance Registry System: 2-Fluoro-4'-hydroxy-3',4',5',6'-tetrahydro-2'H[3,4']bipyridinyl-1'-carboxylic acid(161610-13-5)

Safety Data

• Hazardous Substances Data: 161610-13-5(Hazardous Substances Data)

Upstream product

• 372-48-5 2-fluoropyridine 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 

Downstream Products

• 161610-14-6 1-benzyloxycarbonyl-4-(2-fluoropyrid-3-yl)-1,2,3,6-tetrahydropyridine 

Relevant articles and documents

Investigation of an alternative route to ZD3638 and cost-benefit analysis comparison of raw materials with the previous route

A convergent synthesis to ZD3638 was proposed starting with alternative raw materials. A cost-benefit analysis for the new route was performed which demonstrated that significant savings in raw materials costs could be made over the previous linear sequence. The convergent route was then proved in principle by experimental work. LiTMP was shown to be a superior base to LDA in the modified lithiation reaction.