16162-70-2Relevant academic research and scientific papers
Hypervalent iodine mediated direct one pot transformation of aldehydes to ketones
Sagara, Prateep Singh,Chebolu, Rajesh,Bahuguna, Ashish,Ravikumar
, p. 15011 - 15013 (2014/04/17)
An environmentally benign, step economical synthesis of ketones directly from aldehydes has been developed using hypervalent iodine as an oxidant. The key features of this protocol are its mild conditions without the use of any heavy and toxic metals for the synthesis of a wide range of ketones. the Partner Organisations 2014.
Synthesis and description of chalcone-like compounds, inhibitors of aldose reductase
Severi,Costantino,Benvenuti,Vampa,Mucci
, p. 128 - 136 (2007/10/03)
A series of hydroxy- and hydroxy-methoxychalcones was synthesized and the inhibitory activity and selectivity of the compounds towards bovine lens aldose reductase (AR) were tested. All the compounds display affinity for AR. The most active proved to be 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)propen-1-one (isoliquiritigenin, IC50= 7.60 μM). The selectivity of this compound was also tested, its inhibitory activity being assayed against glutathione reductase and sorbitol dehydrogenase.
