1616340-68-1

Basic information

• Product Name: Methyl-5-(2,4-difluorobenzylcarbaMoyl)-1-(2,2-diMethoxyethyl)-3-Methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate
• Synonyms: Methyl-5-(2,4-difluorobenzylcarbaMoyl)-1-(2,2-diMethoxyethyl)-3-Methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate
• CAS NO: 1616340-68-1
• Molecular Weight: 440.401
• Mol File: 1616340-68-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Methyl-5-(2,4-difluorobenzylcarbaMoyl)-1-(2,2-diMethoxyethyl)-3-Methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-5-(2,4-difluorobenzylcarbaMoyl)-1-(2,2-diMethoxyethyl)-3-Methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate(1616340-68-1)
• EPA Substance Registry System: Methyl-5-(2,4-difluorobenzylcarbaMoyl)-1-(2,2-diMethoxyethyl)-3-Methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate(1616340-68-1)

Safety Data

• Hazardous Substances Data: 1616340-68-1(Hazardous Substances Data)

Usage

General Description

Methyl-5-(2,4-difluorobenzylcarbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate is a complex organic compound with a long chemical name. It is a dihydropyridine derivative that is commonly used in the pharmaceutical industry for its potential therapeutic properties. Methyl-5-(2,4-difluorobenzylcarbaMoyl)-1-(2,2-diMethoxyethyl)-3-Methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate is believed to have anti-hypertensive, calcium channel blocking, and vasodilatory effects, making it useful in the treatment of various cardiovascular conditions. Its chemical structure and properties make it a valuable component in the development of new drugs and medications aimed at improving cardiovascular health.

Upstream product

• 72235-52-0 2,4-Difluoro-benzylamine 
• 127958-23-0 methyl 2-[(dimethylamino)methylene]-4-methoxy-3-oxobutanoate 
• 41051-15-4 4-methoxyacetoacetic acid methylester 
• 553-90-2 Dimethyl oxalate 
• 124-41-4 sodium methylate 
• 1335210-23-5 1-[2,2-bis(methyloxy)ethyl]-5-(methyloxy)-6-[(methyloxy)carbonyl]-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid 
• 1335210-26-8 methyl 2-(((2,2-dimethoxyethyl)amino)methylene)-4-methoxy-3-oxobutanoate 

Downstream Products

• 1616340-96-5 C₂₂H₂₁F₂N₃O₅ 
• 1616342-10-9 C₂₂H₂₁F₂N₃O₅ 
• 1611493-56-1 (2R,5S,13aR)-N-(2,4-difluorobenzyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide 
• 1611493-57-2 (2S,5R,13aS)-N-(2,4-difluorobenzyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide 
• 1616340-16-9 N-(2,4-difluorobenzyl)-9-hydroxy-8,10-dioxo-2,3,5,6,8,10,14,14a-octahydro-2,6-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,6,3]dioxazocine-11-carboxamide 
• 1616340-17-0 N-(2,4-difluorobenzyl)-9-hydroxy-8,10-dioxo-2,3,5,6,8,10,14,14a-octahydro-2,6-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,6,3]dioxazocine-11-carboxamide 
• 1616342-13-2 C₂₂H₂₁F₂N₃O₆ 
• 1616339-70-8 (1S,4R)-N-(2,4-difluorobenzyl)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-1,4-methanopyrido[1',2':4,5]pyrazino[1,2-a]pyrimidine-9-carboxamide 
• 1616339-72-0 (1R,4S)-N-(2,4-difluorobenzyl)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-1,4-methanopyrido[1',2':4,5]pyrazino[1,2-a]pyrimidine-9-carboxamide 
• 1616339-74-2 (2S,6R)-N-(2,4-difluorobenzyl)-9-hydroxy-8,10-dioxo-3,4,5,6,8,10,14,14a-octahydro-2H-2,6-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazocine-11-carboxamide 
• 1616340-69-2 methyl 5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dihydroxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxyiate 
• 1335210-25-7 (4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1’,2’:4,5]pyrazino[2,1-b]oxazine-9-carboxamide 
• 1051375-10-0 (3S,11aR)-N-[(2,4-difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide 
• 1051375-10-0 (3S,11aS)-N-(2,4-difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide 

Relevant articles and documents

Preparation method of multi-tenefavirin open-loop impurities and impurities thereof (by machine translation)

Compared with the prior art, the method disclosed by the invention disclosed by the, invention is A simple in B reaction conditions, and the 1 reaction operation safety, of the 2 impurities of the 3, impurities of the impurities of the 4, impurities and the 5 impurities of the 6, A impurities 6 and the impurities of the impurities and the impurities of the A, impurities B; A B ; A B, A B, B. (by machine translation)

Method for synthesizing diastereomer impurity in dolutegravir raw material

The invention provides a method for synthesizing a diastereomer impurity in a dolutegravir raw material, which comprises the following steps: 1, carrying out condensation reaction on SM1 serving as araw material and 2,4-difluorobenzylamine to generate a compound I; 2, reacting the compound I with an alkali in a reaction solvent to generate a compound II; 3, hydrolyzing the compound II under an acidic condition to generate a compound III; 4, carrying out acid catalytic reaction on the compound III and R-aminobutanol in a reaction solvent to generate a compound IV; 5, generating a compound V from the compound IV in a reaction solvent under the catalysis of a condensing agent; and 6, demethylating the compound V under the action of an alkali metal salt to generate an impurity VI. The synthetic method of the diastereoisomer impurity in the dolutegravir raw material is simple in process and available in raw material, and the prepared new impurity can provide a reference substance for quality analysis of dolutegravir, so that the quality standard of dolutegravir is improved.

A new method for preparing lu Tewei (by machine translation)

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