1616379-83-9

Upstream product

• 486444-34-2 (+)-(R)-3,4-bis((tert-butyldimethylsilyl)oxy)butanal 
• 503604-05-5 (+)-(R)-methyl 3,4-bis((tert-butyldimethylsilyl)oxy)butanoate 
• 1467751-07-0 (R,E)-N-((R)-3,4-bis(tert-butyldimethylsilyloxy)butylidene)-2-methylpropane-2-sulfinamide 
• 1616379-78-2 C₂₄H₄₇NO₄Si 
• 1589-82-8 phenylmagnesium bromide 
• 1616379-68-0 tert-butyl (2R,4S)-2-(tert-butyldimethylsilyloxy)-1-hydroxytridecan-4-ylcarbamate 
• 1616379-54-4 (R)-N-((2R,4S)-1,2-bis(tert-butyldimethylsilyloxy)tridecan-4-yl)-2-methylpropane-2-sulfinamide 

Downstream Products

• 1616379-84-0 (2R,3R,5S)-2-benzyl-3-(tert-butyldimethylsilyloxy)-1-methyl-5-nonylpyrrolidine 
• 119463-16-0 (2R,3R,5S)-2-benzyl-3-hydroxy-1-methyl-5-nonylazolidine 

Relevant academic research and scientific papers

An efficient method for the preparation of 3-hydroxyl-5-substituted 2-pyrrolidones and application in the divergent synthesis of (-)-preussin and its analogues

An asymmetric method to (S,R)-α-hydroxyl-γ-amino alcohols 12 through a diastereoselective addition of Grignard reagents to β-chiral aldimines 11 is described. Subsequent oxidation/cyclization with Sarett reagent provided a novel approach to lactams 14, a flexible building block whose utility was demonstrated in the divergent synthesis of antifungal agent (-)-preussin 5 and its three analogues 23, 24, 25.